Evidence map›Paper›PMID 22231130›Full record

ReviewNature reviews. Nephrology2012

Clinical role of the renal transplant biopsy.

Winfred W Williams, Diana Taheri, Nina Tolkoff-Rubin, Robert B Colvin

Registry-linked trialAbstract readReview
In one paragraph

Review in Nature reviews. Nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03045731 (An US Mathematical Model in Predicting Renal Transplant Rejection), which is not on this map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03045731 unknown statusnot on this mapstarted 2016, after this paper: background citation

An US Mathematical Model in Predicting Renal Transplant Rejection

TypeobservationalSponsorShanghai Zhongshan HospitalRan2016 to 2022Enrolled180ConditionsKidney Transplantation
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Image-guided renal parenchymal biopsies- how we do it.Abdominal radiology (New York) · 2025
    Review
  11. Review
  12. Limitations of biopsy-based transcript diagnostics to detect T-cell-mediated allograft rejection.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  13. Enhancing Predictive Accuracy of Allograft Outcomes: Beyond Traditional Clinical and Biopsy Scoring Methods.Proceedings of SPIE--the International Society for Optical Engineering · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Winfred W WilliamsTransplant Center, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. wwwilliams@ partners.org
Diana Taheri
Nina Tolkoff-Rubin
Robert B Colvin

Funding

Tolerance to Composite Islet-Kidney Transplants in Non-Human PrimatesU19AI102405 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI COSIMI, A BENEDICT · 2012 to 2016
$7.7M
NIAID NIH HHS U19 AI102405
6 · The paper itself

Abstract

Percutaneous needle core biopsy is the definitive procedure by which essential diagnostic and prognostic information on acute and chronic renal allograft dysfunction is obtained. The diagnostic value of the information so obtained has endured for over three decades and has proven crucially important in shaping strategies for therapeutic intervention. This Review provides a broad outline of the utility of performing kidney graft biopsies after transplantation, highlighting the relevance of biopsy findings in the immediate and early post-transplant period (from days to weeks after implantation), the first post-transplant year, and the late period (beyond the first year). We focus on how biopsy findings change over time, and the wide variety of pathological features that characterize the major clinical diagnoses facing the clinician. This article also includes a discussion of acute cellular and humoral rejection, the toxic effects of calcineurin inhibitors, and the widely varying etiologies and characteristics of chronic lesions. Emerging technologies based on gene expression analyses and proteomics, the in situ detection of functionally relevant molecules, and new bioinformatic approaches that hold the promise of improving diagnostic precision and developing new, refined molecular pathways for therapeutic intervention are also presented.

Indexed as

Graft SurvivalBiopsy, NeedleGraft RejectionHumansKidney Failure, ChronicKidney TransplantationPrognosisReproducibility of ResultsSeverity of Illness Index

Identifiers

PMID22231130
PMCPMC3716017

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.