ReviewNature reviews. Gastroenterology & hepatology2012
Diagnosis and management of nonvariceal upper gastrointestinal bleeding.
Review in Nature reviews. Gastroenterology & hepatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical outcomes of over-the-scope-clip system for the treatment of acute upper non-variceal gastrointestinal bleeding: a systematic review and meta-analysis.BMC gastroenterology · 2019Pooled it
- Continuation of enteral nutrition in critically ill patients with nonclinically important nonvariceal upper gastrointestinal bleeding: A retrospective cohort study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Article
- Effectiveness of nasogastric tube decompression in mitigating delayed bleeding following endoscopic submucosal dissection for early gastric cancers.Surgical endoscopy · 2025Article
- A 13-year nationwide analysis of outcomes of non-variceal upper gastrointestinal bleeding in post-bariatric surgery patients.Translational gastroenterology and hepatology · 2025Article
- Transarterial Embolization for Active Gastrointestinal Bleeding: Predictors of Early Mortality and Early Rebleeding.Journal of personalized medicine · 2022Article
- Endoscopic Ultrasound-Guided Treatments for Non-Variceal Upper GI Bleeding: A Review of the Literature.Journal of clinical medicine · 2020Review
- Refractory Nonvariceal Upper Gastrointestinal Bleeding Requiring Surgical Intervention.Cureus · 2019Article
- What Is the Best Endoscopic Strategy in Acute Non-variceal Gastrointestinal Bleeding?Current treatment options in gastroenterology · 2018Review
- Scoring systems for peptic ulcer bleeding: Which one to use?World journal of gastroenterology · 2017Article
- Relevance of surgery in patients with non-variceal upper gastrointestinal bleeding.Langenbeck's archives of surgery · 2017Article
- Predictive Factors for Endoscopic Visibility and Strategies for Pre-endoscopic Prokinetics Use in Patients with Upper Gastrointestinal Bleeding.Digestive diseases and sciences · 2015Article
- Endoscopic management of nonvariceal upper gastrointestinal bleeding: state of the art.Clinical endoscopy · 2015Review
- Relevance of surgery after embolization of gastrointestinal and abdominal hemorrhage.World journal of surgery · 2014Article
- Gastrointestinal bleeding: Matters of life and death: long-term mortality after nonvariceal upper gastrointestinal bleeding.Nature reviews. Gastroenterology & hepatology · 2013Article
- A pilot study of single-use endoscopy in screening acute gastrointestinal bleeding.World journal of gastroenterology · 2013Article
- Managing acute upper gastrointestinal bleeding in the acute assessment unit.Clinical medicine (London, England) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonvariceal upper gastrointestinal bleeding (UGIB) is a major cause of morbidity and mortality worldwide. Despite the improvements in the management of this condition in western countries, mortality rates have remained at 5-10% over the past decade. This article presents the main recommendations for the management of UGIB. Pre-endoscopic management (including use of scoring scales, nasogastric tube placement and blood pressure stabilization) is crucial for triage and optimal resuscitation of patients, and should include a multidisciplinary approach at an early stage. Unless the patient has specific comorbidities, transfusion should only be considered if their hemoglobin level is ≤70 g/l. Endoscopic therapy, the cornerstone of therapeutic management of high-risk lesions, should not be delayed for more than 24 h following admission. Several endoscopic techniques, mostly using clips or thermal methods, are available and new approaches are emerging. When endoscopy fails, surgery or arterial embolization should be considered. Although the efficacy of prokinetics and high-dose intravenous PPI prior to endoscopy is controversial, the use of an intravenous PPI following endoscopy is strongly recommended. Antiplatelet therapy should be suspended and resumed in 3-5 days. Finally, all patients should be tested for Helicobacter pylori by serology in the acute setting.
Indexed as
Identifiers
22230903What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.