Evidence map›Paper›PMID 22230826›Full record

Trial reportAnnals of family medicine

Integrated management of type 2 diabetes mellitus and depression treatment to improve medication adherence: a randomized controlled trial.

Hillary R Bogner, Knashawn H Morales, Heather F de Vries, Anne R Cappola

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of family medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 24 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 24 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 24 syntheses or guidelines pooled it.

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  13. Effect of telemedicine on glycated hemoglobin in diabetes: a systematic review and meta-analysis of randomized trials.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2017
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  16. Consultation liaison in primary care for people with mental disorders.The Cochrane database of systematic reviews · 2015
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Hillary R BognerDepartment of Family Medicine and Community Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. hillary.bogner@uphs.upenn.edu
Knashawn H Morales
Heather F de Vries
Anne R Cappola

Funding

EVOLUTION OF PSYCHOPATHOLOGY IN THE POPULATIONR01MH047447 · NIMH · JOHNS HOPKINS UNIVERSITY · PI EATON, WILLIAM W · 1992 to 2006
$5.3M
Course and risk factors for depression in late lifeR01MH082799 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BOGNER, HILLARY R · 2009 to 2010
$798k
Measurement Error in Latent Class Models of AdherenceK01MH073903 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MORALES, KNASHAWN HODGE · 2007 to 2011
$689k
NIMH NIH HHS K01 MH073903NIMH NIH HHS MH047447NIMH NIH HHS MH073903NIMH NIH HHS MH082799NIMH NIH HHS R01 MH047447NIMH NIH HHS R01 MH082799
6 · The paper itself

Abstract

purposeDepression commonly accompanies diabetes, resulting in reduced adherence to medications and increased risk for morbidity and mortality. The objective of this study was to examine whether a simple, brief integrated approach to depression and type 2 diabetes mellitus (type 2 diabetes) treatment improved adherence to oral hypoglycemic agents and antidepressant medications, glycemic control, and depression among primary care patients.

methodsWe undertook a randomized controlled trial conducted from April 2010 through April 2011 of 180 patients prescribed pharmacotherapy for type 2 diabetes and depression in primary care. Patients were randomly assigned to an integrated care intervention or usual care. Integrated care managers collaborated with physicians to offer education and guideline-based treatment recommendations and to monitor adherence and clinical status. Adherence was assessed using the Medication Event Monitoring System (MEMS). We used glycated hemoglobin (HbA(1c)) assays to measure glycemic control and the 9-item Patient Health Questionnaire (PHQ-9) to assess depression.

resultsIntervention and usual care groups did not differ statistically on baseline measures. Patients who received the intervention were more likely to achieve HbA(1c) levels of less than 7% (intervention 60.9% vs. usual care 35.7%; P < .001) and remission of depression (PHQ-9 score of less than 5: intervention 58.7% vs. usual care 30.7%; P < .001) in comparison with patients in the usual care group at 12 weeks.

conclusionsA randomized controlled trial of a simple, brief intervention integrating treatment of type 2 diabetes and depression was successful in improving outcomes in primary care. An integrated approach to depression and type 2 diabetes treatment may facilitate its deployment in real-world practices with competing demands for limited resources.

Indexed as

Medication AdherencePatient Care TeamAdultAgedAntidepressive AgentsBlood GlucoseDepressive DisorderDiabetes Mellitus, Type 2FemaleHumansHypoglycemic AgentsLinear ModelsMaleMiddle AgedPhiladelphiaPrimary Health CareAntidepressive AgentsBlood GlucoseHypoglycemic Agents

Identifiers

PMID22230826
PMCPMC3262455

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.