ArticleJournal of neuroscience methods2012
Extracellular diffusion in laminar brain structures exemplified by hippocampus.
Article in Journal of neuroscience methods, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
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- Spatial Organization and Dynamics of the Extracellular Space in the Mouse Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Current Techniques for Investigating the Brain Extracellular Space.Frontiers in neuroscience · 2020Review
- ECS Dynamism and Its Influence on Neuronal Excitability and Seizures.Neurochemical research · 2019Review
- Unveiling the Extracellular Space of the Brain: From Super-resolved Microstructure toThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- Brain extracellular space, hyaluronan, and the prevention of epileptic seizures.Reviews in the neurosciences · 2017Review
- Brain Extracellular Space: The Final Frontier of Neuroscience.Biophysical journal · 2017Review
- Real-time Iontophoresis with Tetramethylammonium to Quantify Volume Fraction and Tortuosity of Brain Extracellular Space.Journal of visualized experiments : JoVE · 2017Article
- Anomalous extracellular diffusion in rat cerebellum.Biophysical journal · 2015Article
- The quest for a better insight into physiology of fluids and barriers of the brain: the exemplary career of Joseph D. Fenstermacher.Fluids and barriers of the CNS · 2015Review
- Hyaluronan deficiency due to Has3 knock-out causes altered neuronal activity and seizures via reduction in brain extracellular space.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Numerous brain structures are composed of distinct layers and such stratification has a profound effect on extracellular diffusion transport in these structures. We have derived a more general form of diffusion equation incorporating inhomogeneities in both the extracellular volume fraction (α) and diffusion permeability (θ). A numerical solution of this equation for a special case of layered environment was employed to analyze diffusion in the CA1 region of hippocampus where stratum pyramidale occupied by the bodies of principal neurons is flanked by stratum radiatum and stratum oriens. Extracellular diffusion in the CA1 region was measured in vitro by real-time iontophoretic and real-time pressure methods, and numerical analysis found that stratum pyramidale had a significantly smaller extracellular volume fraction (α=0.127) and lower diffusion permeability (θ=0.327) than the other two layers (α=0.218, θ=0.447). Stratum pyramidale thus functioned as a diffusion barrier for molecules attempting to cross it. We also demonstrate that unless the detailed properties of all layers are taken into account when diffusion experiments are interpreted, the extracted apparent parameters of the extracellular space lose their physical meaning and capacity to describe any individual layer. Such apparent parameters depend on diffusion distance and direction, giving a false impression of microscopic anisotropy and non-Gaussian behavior. This finding has implications for all diffusion mediated physiological processes as well as for other diffusion methods including integrative optical imaging and diffusion-weighted magnetic resonance imaging.
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Registered trials
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