Trial reportHealth and quality of life outcomes2012
The validity and precision of the Leicester Cough Questionnaire in COPD patients with chronic cough.
Trial report in Health and quality of life outcomes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01071161 (Phase III), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase III (c) The Effect of Azithromycin in Patients With COPD and Chronic Productive Cough
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of pharmacotherapeutic clinical trial end-points for bronchiectasis in adults.European respiratory review : an official journal of the European Respiratory Society · 2019Pooled it
- Tools for assessing outcomes in studies of chronic cough: CHEST guideline and expert panel report.Chest · 2015Guideline
- A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial.Nature medicine · 2025Trial
- Nicotine-Free E-Cigarettes Might Promote Tobacco Smoking Reduction Better Than Nicotine Delivery Devices: Results of a Double-Blind Randomized Controlled Trial at 1 Year.Current oncology (Toronto, Ont.) · 2022Trial
- Treatment of urinary incontinence in women with chronic obstructive pulmonary disease-a randomised controlled study.Trials · 2021Trial
- Azithromycin and cough-specific health status in patients with chronic obstructive pulmonary disease and chronic cough: a randomised controlled trial.Respiratory research · 2013Trial
- Leicester Cough Questionnaire validation and clinically important thresholds for change in refractory or unexplained chronic cough.Therapeutic advances in respiratory diseaseTrial
- Cross-cultural validation and reliability of the Leicester Cough Questionnaire in a Danish population.Annals of medicine · 2026Article
- Article
- Cough in pulmonary rehabilitation: a retrospective analysis of responders and nonresponders.ERJ open research · 2025Article
- Determinants of cough-related quality of life in interstitial lung diseases.BMC pulmonary medicine · 2024Article
- Interest of the Leicester Cough Questionnaire in predicting postoperatives complications after lung resection: LCQ-SURGE.Journal of thoracic disease · 2024Article
- Cross-cultural adaptation and validation of Leicester Cough Questionnaire in sarcoidosis: the persian version.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2024Article
- Chronic cough in postmenopausal women and its associations to climacteric symptoms.BMC women's health · 2023Article
- Efficacy and tolerability of zinc acetate for treatment of chronic refractory cough: pilot randomised futility trial.ERJ open research · 2023Article
- Chronic cough-the limitation and advances in assessment techniques.Journal of thoracic disease · 2022Review
- Palliative Care Early in the Care Continuum among Patients with Serious Respiratory Illness: An Official ATS/AAHPM/HPNA/SWHPN Policy Statement.American journal of respiratory and critical care medicine · 2022Article
- Article
- Patient-reported outcomes and patient-reported outcome measures in interstitial lung disease: where to go from here?European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA validated instrument to assess the effects of chronic cough on health status in patients with chronic obstructive pulmonary disease (COPD) is currently not available. The Leicester Cough Questionnaire (LCQ) is a cough-specific health status questionnaire which is originally validated for a population of general patients presenting with chronic cough. We examined the psychometric performance of the LCQ in patients with COPD and chronic productive cough.
methodsConcurrent validity, internal consistency, reproducibility and responsiveness were determined. The St. George's Respiratory Questionnaire (SGRQ) and the Short Form-36 (SF-36) were used as external criteria. Questionnaires were completed at the start of the study. After 2 and 12 weeks the LCQ was repeated, together with a global rating of change.
resultsIn total 54 patients were included. Concurrent validity analysis showed significant correlations between corresponding domains of the LCQ and the SGRQ (r(s) -0.31 to -0.60). Corresponding domains of the LCQ and the SF-36 showed weaker correlations (r(s) 0.04 to 0.41). Internal consistency was adequate for two of the three domains (Cronbach's α 0.74 - 0.86). Test-retest reliability in stable patients was high (intraclass correlation coefficients 0.79 - 0.93). The mean difference after two weeks was 0.73 (± 1.75). Responsiveness analysis indicated that the LCQ was able to detect changes after 12 weeks.
conclusionThe LCQ is a valid, reliable, responsive instrument to measure health status in COPD patients with chronic productive cough.
trial registrationClinicalTrials.gov: NCT01071161.
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