ArticleDNA repair2012
Exonuclease 1 (EXO1) gene variation and melanoma risk.
Article in DNA repair, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Genetic variants in the folate metabolic pathway genes predict cutaneous melanoma-specific survival.The British journal of dermatology · 2020Pooled it
- Genetic variants in TKT and DERA in the nicotinamide adenine dinucleotide phosphate pathway predict melanoma survival.European journal of cancer (Oxford, England : 1990) · 2020Pooled it
- Associations between Nine Polymorphisms in EXO1 and Cancer Susceptibility: A Systematic Review and Meta-Analysis of 39 Case-control Studies.Scientific reports · 2016Pooled it
- EXO1's pan-cancer roles: diagnostic, prognostic, and immunological analyses through bioinformatics.Discover oncology · 2025Article
- Deciphering the multifaceted role ofFrontiers in immunology · 2025Article
- Chromosome-level reference genomes of two imperiled desert fishes: spikedace (Meda fulgida) and loach minnow (Tiaroga cobitis).G3 (Bethesda, Md.) · 2023Article
- Exonucleases: Degrading DNA to Deal with Genome Damage, Cell Death, Inflammation and Cancer.Cells · 2022Review
- Genetic variants of SDCCAG8 and MAGI2 in mitosis-related pathway genes are independent predictors of cutaneous melanoma-specific survival.Cancer science · 2021Article
- Association of genetic variants ofAnnals of translational medicine · 2021Article
- A Novel Four-Gene Signature as a Potential Prognostic Biomarker for Hepatocellular Carcinoma.Journal of oncology · 2021Article
- Genetic variants ofAmerican journal of cancer research · 2021Article
- Genetic variants in PDSS1 and SLC16A6 of the ketone body metabolic pathway predict cutaneous melanoma-specific survival.Molecular carcinogenesis · 2020Article
- Novel Genetic Variants ofCancers · 2020Article
- Novel genetic variants ofAmerican journal of cancer research · 2020Article
- Genetic variants in ELOVL2 and HSD17B12 predict melanoma-specific survival.International journal of cancer · 2019Article
- Genetic variants in the calcium signaling pathway genes are associated with cutaneous melanoma-specific survival.Carcinogenesis · 2019Article
- Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival.International journal of cancer · 2018Article
- Adaptive combination of Bayes factors as a powerful method for the joint analysis of rare and common variants.Scientific reports · 2017Article
- Genetic variants of PDGF signaling pathway genes predict cutaneous melanoma survival.Oncotarget · 2017Article
- Genetic Variants in WNT2B and BTRC Predict Melanoma Survival.The Journal of investigative dermatology · 2017Article
Corrections and comments
- Erratum issuedZhan, Jiangwen [corrected to Zhang, Jiangwen]
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveDNA repair pathway genes play an important role in maintaining genomic integrity and protecting against cancer development. This study aimed to identify novel SNPs in the DNA repair-related genes associated with melanoma risk from a genome-wide association study (GWAS).
methodsA total of 8422 SNPs from the 165 DNA repair-related genes were extracted from a GWAS of melanoma risk, including 494 cases and 5628 controls from the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). We further replicated the top SNPs in a GWAS of melanoma risk from the MD Anderson Cancer Center (1804 cases and 1026 controls).
resultsA total of 3 SNPs with P value <0.001 were selected for in silico replication. One SNP was replicated: rs3902093 [A] in EXO1 promoter region (P(discovery)=6.6 × 10⁻⁴, P(replication)=0.039, P(joint)=2.5 × 10⁻⁴; OR(joint)=0.80, 95% CI: 0.71, 0.90). This SNP was associated with the expression of the EXO1; carriers of the A allele showed lower expression (P=0.002).
conclusionOur study found that a promoter region SNP in the editing and processing nucleases gene EXO1 was associated with decreased expression of EXO1 and decreased melanoma risk. Further studies are warranted to validate this association and to investigate the potential mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.