ArticleBreast cancer research : BCR2012
Balancing harms and benefits of service mammography screening programs: a cohort study.
Article in Breast cancer research : BCR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Recommendations on screening for breast cancer in women aged 40-74 years who are not at increased risk for breast cancer.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Guideline
- Quantifying and monitoring overdiagnosis in cancer screening: a systematic review of methods.BMJ (Clinical research ed.) · 2015Pooled it
- Pooled it
- Characteristics of breast cancers detected by screening mammography in Taiwan: a single institute's experience.BMC women's health · 2023Article
- Overdiagnosis Due to Screening Mammography for Breast Cancer among Women Aged 40 Years and Over: A Systematic Review and Meta-Analysis.Journal of personalized medicine · 2023Review
- Determinants of Intention to Participate in Breast Cancer Screening among Urban Chinese Women: An Application of the Protection Motivation Theory.International journal of environmental research and public health · 2021Article
- Effectiveness of the Korean National Cancer Screening Program in reducing breast cancer mortality.NPJ breast cancer · 2021Article
- The potential of breast cancer screening in Europe.International journal of cancer · 2021Article
- Review
- A Validation of Methods for the Evaluation of Observational Studies of Screening Mammography: An Exploratory Analysis Based on Simulating Screening Cohorts.Clinical epidemiology · 2020Article
- Fake facts and alternative truths in medical research.BMC medical ethics · 2018Article
- Effect of population breast screening on breast cancer mortality up to 2005 in England and Wales: an individual-level cohort study.British journal of cancer · 2017Article
- Mammography, Martin Yaffe, and me: response and appreciation.Current oncology (Toronto, Ont.) · 2015Article
- Overdiagnosis: epidemiologic concepts and estimation.Epidemiology and health · 2015Article
- Overdiagnosis due to breast cancer screening: updated estimates of the Helsinki service study in Finland.British journal of cancer · 2014Article
- Were our estimates of overdiagnosis with mammography screening in the United States "based on faulty science"?The oncologist · 2014Article
- [Limits of mammography screening: current controversies and perspectives].Der Radiologe · 2013Article
- Overdiagnosis among women attending a population-based mammography screening program.International journal of cancer · 2013Article
- The benefits and harms of breast cancer screening: an independent review.British journal of cancer · 2013Review
- Cost effectiveness of the NHS breast screening programme: life table model.BMJ (Clinical research ed.) · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe use of screening mammography is still under debate within the medical community. The aim of this study is to define a balance sheet of benefits (breast cancer mortality reduction) and harms (overdiagnosis) for mammography screening programs.
methodsWe compared breast cancer incidence and mortality in two cohorts of women, defined as 'attenders' or 'non-attenders' on the basis of the individual attitudes towards screening, who were invited to the first round of the Florentine screening program. The effects of screening exposure on breast cancer incidence and mortality were evaluated by fitting Poisson regression models adjusted for age at entry, marital status and deprivation index. We performed a sensitivity analysis excluding 34 women not responding to the invitation with a breast cancer diagnosis in the following six months.
resultsIn total, we included 51,096 women aged 50 to 69 years invited at the first screening round (1991 to 1993) and followed-up for breast cancer incidence and mortality until 31 December 2007 and 31 December 2008, respectively The estimate of mortality reduction varies from 45% among 50 to 59 year-old women up to 51% among 60 to 69 year-old women. The estimate of overdiagnosis, according to the cumulative-incidence method, is an additional 10% of all breast cancer cases among 60 to 69 year-old women screened.
conclusionsComparing the breast cancer mortality and breast cancer incidence between attenders and non-attenders, we have determined that the overall cost to save one life corresponds to no more than one over-diagnosed tumor (from 0.6 to 1 depending on the selection criteria of the cohort), even if a residual self-selection bias cannot be excluded.
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