ReviewArchives of biochemistry and biophysics2012
Recent advances in our understanding of 1,25-dihydroxyvitamin D(3) regulation of intestinal calcium absorption.
Review in Archives of biochemistry and biophysics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Pooled it
- Vitamin D-binding protein levels do not influence the effect of vitamin D repletion on serum PTH and calcium: data from a randomized, controlled trial.The Journal of clinical endocrinology and metabolism · 2014Trial
- Vitamins in the Treatment of Periodontitis: Molecular Mechanism and Network Pharmacological Analysis.Oral health & preventive dentistry · 2025Review
- Hereditary Rickets: A Quick Guide for the Pediatrician.Current pediatric reviews · 2024Review
- Vitamin D and Calcium and Bioavailability of Calcium in Various Calcium Salts.Indian journal of orthopaedics · 2023Review
- Vitamin DAnimals : an open access journal from MDPI · 2022Article
- The Formation, Structural Characteristics, Absorption Pathways and Bioavailability of Calcium-Peptide Chelates.Foods (Basel, Switzerland) · 2022Review
- Dietary branched-chain amino acids modulate the dynamics of calcium absorption and reabsorption in protein-restricted pigs.Journal of animal science and biotechnology · 2022Article
- Contributions of SGK3 to transporter-related diseases.Frontiers in cell and developmental biology · 2022Review
- Calcium and Vitamin D Supplementation and Their Association with Kidney Stone Disease: A Narrative Review.Nutrients · 2021Review
- Vitamin D: A Critical Regulator of Intestinal Physiology.JBMR plus · 2021Review
- Dietary vitamin D intake and colorectal cancer risk: a longitudinal approach within the PREDIMED study.European journal of nutrition · 2021Article
- Vitamin D and COVID-19: A review on the role of vitamin D in preventing and reducing the severity of COVID-19 infection.Protein science : a publication of the Protein Society · 2021Review
- Review
- Article
- Analysis of 1,25-Dihydroxyvitamin DMolecular and cellular biology · 2020Article
- Intestinal CaWorld journal of gastroenterology · 2020Review
- Article
- Targeted genomic deletions identify diverse enhancer functions and generate a kidney-specific, endocrine-deficientThe Journal of biological chemistry · 2019Article
- Anticancer activity of 1,25-(OH)OncoTargets and therapy · 2019Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Calcium is required for many cellular processes including muscle contraction, nerve pulse transmission, stimulus secretion coupling and bone formation. The principal source of new calcium to meet these essential functions is from the diet. Intestinal absorption of calcium occurs by an active transcellular path and by a non-saturable paracellular path. The major factor influencing intestinal calcium absorption is vitamin D and more specifically the hormonally active form of vitamin D, 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)). This article emphasizes studies that have provided new insight related to the mechanisms involved in the intestinal actions of 1,25(OH)(2)D(3). The following are discussed: recent studies, including those using knock out mice, that suggest that 1,25(OH)(2)D(3) mediated calcium absorption is more complex than the traditional transcellular model; evidence for 1,25(OH)(2)D(3) mediated active transport of calcium by distal as well as proximal segments of the intestine; 1,25(OH)(2)D(3) regulation of paracellular calcium transport and the role of 1,25(OH)(2)D(3) in protection against mucosal injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.