Evidence map›Paper›PMID 22230254›Full record

ArticlePhysiology & behavior2012

Chorda tympani nerve modulates the rat's avoidance of calcium chloride.

Glen J Golden, Anna Voznesenskaya, Michael G Tordoff

Open access · greenAbstract read
In one paragraph

Article in Physiology & behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Glen J GoldenMonell Chemical Senses Center, 3500 Market Street, Philadelphia, PA, USA.
Anna Voznesenskaya
Michael G Tordoff
Monell Chemical Senses Center · US

Funding

PHYSIOLOGY OF CALCIUM APPETITER01DK046791 · NIDDK · MONELL CHEMICAL SENSES CENTER · PI TORDOFF, MICHAEL G · 1994 to 2013
$5.5M
Molecular BiologyP30DC011735 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI REED, DANIELLE RENEE · 2011 to 2015
$2.5M
Genetics of taste preferencesR01DC010149 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI TORDOFF, MICHAEL G · 2010 to 2014
$1.5M
NIDCD NIH HHS DC-10149NIDCD NIH HHS P30 DC011735NIDCD NIH HHS R01 DC010149NIDDK NIH HHS R01 DK046791
6 · The paper itself

Abstract

Calcium intake depends on orosensory factors, implying the presence of a mechanism for calcium detection in the mouth. To better understand how information about oral calcium is conveyed to the brain, we examined the effects of chorda tympani nerve transection on calcium chloride (CaCl(2)) taste preferences and thresholds in male Wistar rats. The rats were given bilateral transections of the chorda tympani nerve (CTX) or control surgery. After recovery, they received 48-h two-bottle tests with an ascending concentration series of CaCl(2). Whereas control rats avoided CaCl(2) at concentrations of 0.1mM and higher, rats with CTX were indifferent to CaCl(2) concentrations up to 10mM. Rats with CTX had significantly higher preference scores for 0.316 and 3.16 mM CaCl(2) than did control rats. The results imply that the chorda tympani nerve is required for the normal avoidance of CaCl(2) solution.

Indexed as

Calcium ChlorideAdministration, OralAfferent PathwaysAnimalsAssociation LearningAvoidance LearningChorda Tympani NerveCranial Nerve InjuriesDose-Response Relationship, DrugMaleRatsRats, WistarTasteTaste ThresholdCalcium Chloride

Identifiers

PMID22230254
PMCPMC3285452
OpenAlexW2030345799

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.