ArticleThe Biochemical journal2012
A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3).
Article in The Biochemical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
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- Molecular mechanisms involved in regulating protein activity and biological function of MST3.Cell division · 2023Review
- NDR kinase tricornered genetically interacts with Ccm3 and metabolic enzymes in Drosophila melanogaster tracheal development.G3 (Bethesda, Md.) · 2023Article
- MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins.The Biochemical journal · 2021Article
- Not the comfy chair! Cancer drugs that act against multiple active sites.Expert opinion on therapeutic targets · 2019Review
- IntFOLD: an integrated web resource for high performance protein structure and function prediction.Nucleic acids research · 2019Article
- Genomic and transcriptomic characterisation of undifferentiated pleomorphic sarcoma of bone.The Journal of pathology · 2019Article
- Mammalian Sterile20-like Kinases: Signalings and Roles in Central Nervous System.Aging and disease · 2018Review
- Protein Kinase Serine/Threonine Kinase 24 Positively Regulates Interleukin 17-Induced Inflammation by Promoting IKK Complex Activation.Frontiers in immunology · 2018Article
- The MST3/STK24 kinase mediates impaired fasting blood glucose after a high-fat diet.Diabetologia · 2017Article
- MST3 promotes proliferation and tumorigenicity through the VAV2/Rac1 signal axis in breast cancer.Oncotarget · 2016Article
- MST kinases in development and disease.The Journal of cell biology · 2015Review
- Disorder Prediction Methods, Their Applicability to Different Protein Targets and Their Usefulness for Guiding Experimental Studies.International journal of molecular sciences · 2015Review
- MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development.Neuron · 2014Article
- An unbiased proteomic screen reveals caspase cleavage is positively and negatively regulated by substrate phosphorylation.Molecular & cellular proteomics : MCP · 2014Article
- Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The FunFOLD2 server for the prediction of protein-ligand interactions.Nucleic acids research · 2013Article
- Structural insights into the activation of MST3 by MO25.Biochemical and biophysical research communications · 2013Article
- Germinal center kinases in immune regulation.Cellular & molecular immunology · 2012Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The canonical pathway of regulation of the GCK (germinal centre kinase) III subgroup member, MST3 (mammalian Sterile20-related kinase 3), involves a caspase-mediated cleavage between N-terminal catalytic and C-terminal regulatory domains with possible concurrent autophosphorylation of the activation loop MST3(Thr(178)), induction of serine/threonine protein kinase activity and nuclear localization. We identified an alternative 'non-canonical' pathway of MST3 activation (regulated primarily through dephosphorylation) which may also be applicable to other GCKIII (and GCKVI) subgroup members. In the basal state, inactive MST3 co-immunoprecipitated with the Golgi protein GOLGA2/gm130 (golgin A2/Golgi matrix protein 130). Activation of MST3 by calyculin A (a protein serine/threonine phosphatase 1/2A inhibitor) stimulated (auto)phosphorylation of MST3(Thr(178)) in the catalytic domain with essentially simultaneous cis-autophosphorylation of MST3(Thr(328)) in the regulatory domain, an event also requiring the MST3(341-376) sequence which acts as a putative docking domain. MST3(Thr(178)) phosphorylation increased MST3 kinase activity, but this activity was independent of MST3(Thr(328)) phosphorylation. Interestingly, MST3(Thr(328)) lies immediately C-terminal to a STRAD (Sterile20-related adaptor) pseudokinase-like site identified recently as being involved in binding of GCKIII/GCKVI members to MO25 scaffolding proteins. MST3(Thr(178)/Thr(328)) phosphorylation was concurrent with dissociation of MST3 from GOLGA2/gm130 and association of MST3 with MO25, and MST3(Thr(328)) phosphorylation was necessary for formation of the activated MST3-MO25 holocomplex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.