ArticleDiabetes care2012
Variants in the SIRT1 gene may affect diabetes risk in interaction with prenatal exposure to famine.
Article in Diabetes care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 48 citations in OpenAlex.
- Trial
- LinkingMolecular biology research communications · 2026Article
- Article
- Increased Preeclampsia Risk in GDM Pregnancies: The Role of SIRT1 rs12778366 Polymorphism and Telomere Length.International journal of molecular sciences · 2025Article
- Effect of SIRT1 gene single-nucleotide polymorphisms on susceptibility to type 1 diabetes in a Han Chinese population.Journal of endocrinological investigation · 2024Article
- Prenatal caloric restriction adjusts the energy homeostasis and behavior in response to acute and chronic variations in food availability in adulthood.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- Effects of prenatal exposure to the 1944-45 Dutch famine and glucocorticoid receptor polymorphisms on later life PTSD susceptibility.European journal of psychotraumatology · 2023Article
- Genetic Variants ofInternational journal of endocrinology · 2023Article
- A natural genetic variation screen identifies insulin signaling, neuronal communication, and innate immunity as modifiers of hyperglycemia in the absence of Sirt1.G3 (Bethesda, Md.) · 2022Article
- SIRT1 rs7896005 polymorphism affects major vascular outcomes, not all-cause mortality, in Caucasians with type 2 diabetes: A 13-year observational study.Diabetes/metabolism research and reviews · 2022Observational
- Association of Famine Exposure on the Changing Clinical Phenotypes of Primary Hyperparathyroidism in 20 years.Frontiers in endocrinology · 2022Article
- Early-life exposure to the Chinese famine, genetic susceptibility and the risk of type 2 diabetes in adulthood.Diabetologia · 2021Article
- Cohort profile: the Dutch famine birth cohort (DFBC)- a prospective birth cohort study in the Netherlands.BMJ open · 2021Article
- Sirtuins-The New Important Players in Women's Gynecological Health.Antioxidants (Basel, Switzerland) · 2021Review
- Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1.Frontiers in physiology · 2021Article
- Ten SNPs May Affect Type 2 Diabetes Risk in Interaction with Prenatal Exposure to Chinese Famine.Nutrients · 2020Article
- Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence.Communications biology · 2020Article
- Association of sirtuin 1 gene polymorphisms with nephrolithiasis in Eastern chinese population.Renal failure · 2019Article
- Early-life Programming of Type 2 Diabetes Mellitus: Understanding the Association between Epigenetics/Genetics and Environmental Factors.Current genomics · 2019Review
- Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility.Cardiology research and practice · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether SIRT1, a nutrient-sensing histone deacetylase, influences fetal programming during malnutrition. RESEARCH DESIGN AND
methodsIn 793 individuals of the Dutch Famine Birth Cohort, we analyzed the interaction between three SIRT1 single nucleotide polymorphisms (SNPs) and prenatal exposure to famine on type 2 diabetes risk.
resultsIn the total population (exposed and unexposed), SIRT1 variants were not associated with type 2 diabetes. A significant interaction was found between two SIRT1 SNPs and exposure to famine in utero on type 2 diabetes risk (P = 0.03 for rs7895833; P = 0.01 for rs1467568). Minor alleles of these SNPs were associated with a lower prevalence of type 2 diabetes only in individuals who had been exposed to famine prenatally (odds ratio for rs7895833 0.50 [95% CI 0.24-1.03], P = 0.06; for rs1467568 0.48 [0.25-0.91], P = 0.02).
conclusionsSIRT1 may be an important genetic factor involved in fetal programming during malnutrition, influencing type 2 diabetes risk later in life.
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