ArticleDiabetes2012
Common variants of IL6, LEPR, and PBEF1 are associated with obesity in Indian children.
Article in Diabetes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Association between -174G>C polymorphism in the IL-6 promoter region and the risk of obesity: A meta-analysis.Medicine · 2018Pooled it
- Leptin Receptor Gene Variant rs11804091 Is Associated with BMI and Insulin Resistance in Spanish Female Obese Children: A Case-Control Study.International journal of molecular sciences · 2017Trial
- Exploring socio-economic, biochemical, and genetic factors influencing thyroid status in Indian school-going adolescents.Journal of human genetics · 2026Article
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- Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review.Journal of personalized medicine · 2023Review
- Effects of childhood obesity and related genetic factors on precocious puberty: protocol for a multi-center prospective cohort study.BMC pediatrics · 2022Article
- Polymorphisms and Gene-Gene Interaction in AGER/IL6 Pathway Might Be Associated with Diabetic Ischemic Heart Disease.Journal of personalized medicine · 2022Article
- Innate-Immunity Genes in Obesity.Journal of personalized medicine · 2021Review
- Computational Functional Genomics-Based AmpliSeq™ Panel for Next-Generation Sequencing of Key Genes of Pain.International journal of molecular sciences · 2021Article
- Leptin Levels and Q223R Leptin Receptor Gene Polymorphism in Obese Mexican Young Adults.EJIFCC · 2020Article
- Multifaceted genome-wide study identifies novel regulatory loci in SLC22A11 and ZNF45 for body mass index in Indians.Molecular genetics and genomics : MGG · 2020Article
- Incendiary Leptin.Nutrients · 2020Review
- Comparison of plasma adipocytokines & C-reactive protein levels in healthy schoolgoing adolescents from private & government-funded schools of Delhi, India.The Indian journal of medical research · 2020Article
- Normative range of blood biochemical parameters in urban Indian school-going adolescents.PloS one · 2019Article
- Genetics of obesity and its measures in India.Journal of genetics · 2018Review
- Food Consumption as a Modifier of the Association betweenNutrients · 2018Article
- Late effects in survivors of childhood acute lymphoblastic leukemia in the context of selected gene polymorphisms.Italian journal of pediatrics · 2018Article
- NAMPT-mediated NADMolecular metabolism · 2018Article
- Common variants of ARID1A and KAT2B are associated with obesity in Indian adolescents.Scientific reports · 2018Article
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
The increasing prevalence of obesity in urban Indian children is indicative of an impending crisis of metabolic disorders. Although perturbations in the secretion of adipokines and inflammatory molecules in childhood obesity are well documented, the contribution of common variants of genes encoding them is not well investigated. We assessed the association of 125 common variants from 21 genes, encoding adipocytokines and inflammatory markers in 1,325 urban Indian children (862 normal weight [NW group] and 463 overweight/obese [OW/OB group]) and replicated top loci in 1,843 Indian children (1,399 NW children and 444 OW/OB children). Variants of four genes (PBEF1 [rs3801266] [P = 4.5 × 10(-4)], IL6 [rs2069845] [P = 8.7 × 10(-4)], LEPR [rs1137100] [P = 1.8 × 10(-3)], and IL6R [rs7514452] [P = 2.1 × 10(-3)]) were top signals in the discovery sample. Associations of rs2069845, rs1137100, and rs3801266 were replicated (P = 7.9 × 10(-4), 8.3 × 10(-3), and 0.036, respectively) and corroborated in meta-analysis (P = 2.3 × 10(-6), 3.9 × 10(-5), and 4.3 × 10(-4), respectively) that remained significant after multiple testing corrections. These variants also were associated with quantitative measures of adiposity (weight, BMI, and waist and hip circumferences). Allele dosage analysis of rs2069845, rs1137100, and rs3801266 revealed that children with five to six risk alleles had an approximately four times increased risk of obesity than children with less than two risk alleles (P = 1.2 × 10(-7)). In conclusion, our results demonstrate the association of the common variants of IL6, LEPR, and PBEF1 with obesity in Indian children.
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