ArticleDiabetes2012
Storage rates of circulating free fatty acid into adipose tissue during eating or walking in humans.
Article in Diabetes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 36 citations in OpenAlex.
- Adipocyte Proteins and Storage of Endogenous Fatty Acids in Visceral and Subcutaneous Adipose Tissue in Severe Obesity.Obesity (Silver Spring, Md.) · 2021Trial
- Regulation of direct adipose tissue free fatty acid storage during mixed meal ingestion and high free fatty acid concentration conditions.American journal of physiology. Endocrinology and metabolism · 2021Trial
- Subcutaneous adipose tissue free fatty acid uptake measured using positron emission tomography and adipose biopsies in humans.American journal of physiology. Endocrinology and metabolism · 2019Trial
- Adipose Tissue Free Fatty Acid Storage In Vivo: Effects of Insulin Versus Niacin as a Control for Suppression of Lipolysis.Diabetes · 2015Trial
- Measuring plasma fatty acid oxidation with intravenous bolus injection of 3H- and 14C-fatty acid.Journal of lipid research · 2013Trial
- Association between different metabolic phenotypes and chronic kidney disease risk: a cohort study.Diabetology & metabolic syndrome · 2026Article
- Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans.Physiological reviews · 2025Review
- Association between triglyceride-glucose index and the risk of type 2 diabetes mellitus.Archives of endocrinology and metabolism · 2025Article
- Relatively lower BMI-adjusted calf circumference is associated with metabolically unhealthy phenotype in non-obese adults: a cross-sectional study.BMC public health · 2024Article
- Influence of Free Fatty Acid Concentrations and Weight Loss on Adipose Tissue Direct Free Fatty Acid Storage Rates.The Journal of clinical endocrinology and metabolism · 2021Article
- Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver.Nature reviews. Endocrinology · 2021Review
- The impact of a high-fat diet in mice is dependent on duration and age, and differs between muscles.The Journal of experimental biology · 2020Article
- Article
- Human adipose tissue protein analyses using capillary western blot technology.Nutrition & diabetes · 2018Article
- Effects of meal ingestion on intramyocellular ceramide concentrations and fractional de novo synthesis in humans.American journal of physiology. Endocrinology and metabolism · 2018Article
- Association of calf circumference with insulin resistance and non-alcohol fatty liver disease: the REACTION study.BMC endocrine disorders · 2017Article
- Adipose tissue fatty acid storage factors: effects of depot, sex and fat cell size.International journal of obesity (2005) · 2015Article
- Sex and depot differences in ex vivo adipose tissue fatty acid storage and glycerol-3-phosphate acyltransferase activity.American journal of physiology. Endocrinology and metabolism · 2015Article
- Biology of upper-body and lower-body adipose tissue--link to whole-body phenotypes.Nature reviews. Endocrinology · 2015Review
- Effects of increased free fatty acid availability on adipose tissue fatty acid storage in men.The Journal of clinical endocrinology and metabolism · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We measured subcutaneous adipose tissue free fatty acid (FFA) storage rates in postprandial and walking conditions to better understand the contributions of this pathway to body fat distribution. Palmitate tracers were infused intravenously and fat biopsies collected to measure palmitate storage in upper- (UBSQ) and lower-body subcutaneous (LBSQ) fat in 41 (17 men) and 40 (16 men) volunteers under postprandial and under postabsorptive walking conditions, respectively. Postprandial palmitate storage was greater in women than men in UBSQ (0.50±0.25 vs. 0.33±0.37 μmol⋅kg fat(-1)⋅min(-1); P=0.007) and LBSQ fat (0.37±0.25 vs. 0.22±0.20 μmol⋅kg fat(-1)⋅min(-1); P=0.005); storage rates were significantly greater in UBSQ than LBSQ fat in both sexes. During walking, UBSQ palmitate storage did not differ between sexes, whereas LBSQ storage was greater in women than men (0.40±0.22 vs. 0.25±0.15 μmol⋅kg fat(-1)⋅min(-1); P=0.01). In women only, walking palmitate storage was significantly greater in LBSQ than UBSQ fat. Adipocyte CD36 and diacylglycerol acyltransferase (DGAT) correlated with LBSQ palmitate storage in the postprandial and walking condition, respectively. We conclude that UBSQ fat is the preferred postprandial FFA storage depot for both sexes, whereas walking favors storage in LBSQ fat in women. Transmembrane transport (CD36) and esterification into triglycerides (DGAT) may be rate-limiting steps for LBSQ FFA storage during feeding and exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.