ArticleAmerican journal of industrial medicine2012
GSTM1 and GSTP1 gene variants and the effect of air pollutants on lung function measures in South African children.
Article in American journal of industrial medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Ambient air pollution and non-communicable respiratory illness in sub-Saharan Africa: a systematic review of the literature.Environmental health : a global access science source · 2022Pooled it
- Mechanisms and therapeutic strategies of asthma: from bench to bedside.Signal transduction and targeted therapy · 2026Review
- Exposure to indoor and outdoor air pollution in schools in Africa: Current status, knowledge gaps, and a call to action.Heliyon · 2023Review
- Environmentally persistent free radicals enhance SARS-CoV-2 replication in respiratory epithelium.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- A Review of theInternational journal of genomics · 2023Review
- Mechanistic Implications of Biomass-Derived Particulate Matter for Immunity and Immune Disorders.Toxics · 2021Review
- A case report of idiopathic environmental intolerance: A controversial and current issue.Clinical case reports · 2020Article
- Environmental Health Research in Africa: Important Progress and Promising Opportunities.Frontiers in genetics · 2019Review
- Article
- Interactions of GST Polymorphisms in Air Pollution Exposure and Respiratory Diseases and Allergies.Current allergy and asthma reports · 2016Review
- Do Variants in GSTs Modify the Association between Traffic Air Pollution and Asthma in Adolescence?International journal of molecular sciences · 2016Article
- Article
- GSTP1 and TNF Gene variants and associations between air pollution and incident childhood asthma: the traffic, asthma and genetics (TAG) study.Environmental health perspectives · 2014Article
- Gender-dependent effect of GSTM1 genotype on childhood asthma associated with prenatal tobacco smoke exposure.BioMed research international · 2014Article
- Allergic diseases and air pollution.Asia Pacific allergy · 2013Article
- Review
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundSeveral genes are associated with an increased susceptibility to asthma, which may be exacerbated by ambient air pollution. These genes include GSTM1 (glutathione-S-transferase M1 gene) and GSTP1 (glutathione-S-transferase P1 gene), which may modulate the response to epithelial oxidative changes caused by air pollutant exposure. This study evaluated fluctuations in the forced expiratory volume in one second (FEV(1)) in relation to lagged daily averages of ambient air pollutants (SO(2), NO(2), NO, and PM(10)) while considering genotype as an effect modifier.
methodsA longitudinal cohort of 129 schoolchildren of African descent from Durban, South Africa was assessed. GSTM1 (null vs. present genotype) and GSTP1 (Ile105Val; AA → AG/GG) genotypes were determined using standard techniques. SO(2), NO(2), NO, and PM(10) were measured continuously over a year using validated methods. The outcome was intraday variability in FEV(1) . Data were collected daily over a 3-week period in each of four seasons (2004-2005).
resultsAmong the children tested, 27% had the GSTM1 null genotype and 81% carried the GSTP1 G allele. Approximately 26 out 104 children (25%) showed evidence of bronchial hyperreactivity, 13% reported having symptoms in keeping with persistent asthma, and a further 25% reported symptoms of mild intermittent asthma. PM(10) and SO(2) levels were moderately high relative to international guidelines. Neither GSTM1 nor GSTP1 genotypes alone were significantly associated with FEV(1) intraday variability. In models not including genotype, FEV(1) variability was statistically significantly associated only with NO(2) for 5-day lags (% change in intraday variability in FEV1 per interquartile range = 1.59, CI 0.58, 2.61). The GSTP1 genotype modified the effect of 3 days prior 24-hr average PM(10) and increased FEV(1) variability. A similar pattern was observed for lagged 3 day SO(2) exposure (P interaction < 0.05). Adverse effects of these pollutants were limited to individuals carrying the G allele for this polymorphism.
conclusionAmong this indigenous South African children cohort, the GSTP1 genotype modified the effects of ambient exposures to PM(10) and SO(2) and lung function. A plausible mechanism for these observed effects is decreased capacity to mount an effective response to oxidative stress associated with the GSTP1 AG + GG genotype.
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