ArticleHead and neck pathology2012
Cytoplasmic ezrin and moesin correlate with poor survival in head and neck squamous cell carcinoma.
Article in Head and neck pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Prognostic Value of Ezrin in Various Cancers: A Systematic Review and Updated Meta-analysis.Scientific reports · 2015Pooled it
- Pooled it
- Identification of lactylation-related biomarkers in HNSC by integrating machine learning and Spatial transcriptomics analysis.Discover oncology · 2025Article
- Homeostatic membrane tension constrains cancer cell dissemination by counteracting BAR protein assembly.Nature communications · 2021Article
- Observational
- Acetylation of ezrin regulates membrane-cytoskeleton interaction underlying CCL18-elicited cell migration.Journal of molecular cell biology · 2020Article
- Immunohistochemical Study of Ezrin Expression in Colorectal Carcinoma: A Comparative Study between Objective Method and Digital Quantitative Assessment.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Moesin expression by tumor cells is an unfavorable prognostic biomarker for oral cancer.BMC cancer · 2018Article
- Detecting the location and significance of Ezrin protein expression in hepatocellular carcinoma.International journal of clinical and experimental pathology · 2018Article
- Immunohistochemical Expression Of Ezrin In Oral Potentially Malignant Disorders-A Descriptive Study.Journal of pharmacy & bioallied sciences · 2017Article
- Apolipoprotein E Promotes Invasion in Oral Squamous Cell Carcinoma.The American journal of pathology · 2017Article
- Podoplanin, ezrin, and Rho-A proteins may have joint participation in tumor invasion of lip cancer.Clinical oral investigations · 2017Article
- Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells.Journal of molecular cell biology · 2016Article
- Willing to Be Involved in Cancer.Genes · 2016Review
- Are podoplanin and ezrin involved in the invasion process of the ameloblastomas?European journal of histochemistry : EJH · 2015Article
- The relationship between ezrin and podoplanin expressions in keratocystic odontogenic tumors.BMC oral health · 2014Article
- ß1 integrin binding phosphorylates ezrin at T567 to activate a lipid raft signalsome driving invadopodia activity and invasion.PloS one · 2013Article
- Presence in the pre-surgical fine-needle aspiration of potential thyroid biomarkers previously identified in the post-surgical one.PloS one · 2013Article
- Mechanisms underlying cancer progression caused by ezrin overexpression in tongue squamous cell carcinoma.PloS one · 2013Article
- To evaluate an association between prognostic significance of Moesin with histopathological grading of oral squamous cell carcinoma: A systematic review.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Members of the 4.1 superfamily of proteins, including ezrin, moesin, merlin, and willin regulate many normal physiologic processes such as cellular shape, motility, and proliferation. In addition, they contribute both to tumor development and tumor progression. We reported previously that strong cytoplasmic ezrin expression was independently associated with poorer patient survival. One hundred and thirty-one histologically confirmed primary head and neck squamous cell carcinomas were examined prospectively for cancer progression and survival at a large health care center in the Bronx, NY, USA. Immunohistochemical analysis of ezrin, moesin, merlin, and willin expression in tissue microarray samples of primary head and neck squamous cell carcinoma revealed a significant association of increased cytoplasmic ezrin with poor cancer survival. Global RNA analyses suggest that cancers with high cytoplasmic ezrin have a more invasive phenotype. This study supports our previous findings associating cytoplasmic ezrin with more aggressive behavior and poorer outcome and indicates the need for a multi-institutional study to validate the use of cytoplasmic ezrin as a biomarker for treatment planning in head and neck squamous cell carcinoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.