ArticleDocumenta ophthalmologica. Advances in ophthalmology2012
Spectral characteristics of the PhNR in the full-field flash electroretinogram of normals and glaucoma patients.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- The luminance-response function of the photopic negative response (PhNR): analysing different stimulation, recording and measurement approaches.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Electroretinography With the RM Electrode: Normative Reference Ranges, Variation With Age, and Comparison With the Burian-Allen Electrode.Translational vision science & technology · 2025Article
- Association analyses of the measurements of the photopic negative response evoked by two ISCEV protocols.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Sustained Experimental Myopia Exacerbates the Effect of Eye Growth on Retinal Ganglion Cell Density and Function.International journal of molecular sciences · 2025Article
- Electroretinographic responses to periodic stimuli in primates and the relevance for visual perception and for clinical studies.Visual neuroscience · 2024Review
- Pre-stimulus bioelectrical activity in light-adapted ERG under blue versus white background.Visual neuroscience · 2023Article
- The diagnostic accuracy of photopic negative responses evoked by broadband and chromatic stimuli in a clinically heterogeneous population.Documenta ophthalmologica. Advances in ophthalmology · 2023Article
- Topographical Correlation between Structural and Functional Impairment of the Macular Inner Retinal Layers in Multiple Sclerosis Eyes with a History of Optic Neuropathy.Journal of clinical medicine · 2023Article
- Utility of Light-Adapted Full-Field Electroretinogram ON and OFF Responses for Detecting Glaucomatous Functional Damage.Translational vision science & technology · 2023Article
- Use of extended protocols with nonstandard stimuli to characterize rod and cone contributions to the canine electroretinogram.Documenta ophthalmologica. Advances in ophthalmology · 2022Article
- The influence of temporal frequency and stimulus size on the relative contribution of luminance and L-/M-cone opponent mechanisms in heterochromatic flicker ERGs.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- Photopic negative response using a handheld mini-ganzfeld stimulator in healthy adults: normative values, intra- and inter-session variability.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- Relationship between stimulus size and different components of the electroretinogram (ERG) elicited by flashed stimuli.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- The photopic negative response (PhNR): measurement approaches and utility in glaucoma.International ophthalmology · 2020Review
- Short-Term Changes in the Photopic Negative Response Following Intraocular Pressure Lowering in Glaucoma.Investigative ophthalmology & visual science · 2020Article
- The photopic negative response of the Light-adapted 3.0 ERG in clinical settings.Documenta ophthalmologica. Advances in ophthalmology · 2020Article
- Comparisons of photopic negative responses elicited by different conditions from glaucomatous eyes.Japanese journal of ophthalmology · 2020Observational
- Comparison between broadband and monochromatic photopic negative response in full-field electroretinogram in controls and subjects with primary open-angle glaucoma.Documenta ophthalmologica. Advances in ophthalmology · 2019Article
- Optimizing a Portable ERG Device for Glaucoma Clinic: The Effect of Interstimulus Frequency on the Photopic Negative Response.Translational vision science & technology · 2018Article
- ISCEV extended protocol for the photopic negative response (PhNR) of the full-field electroretinogram.Documenta ophthalmologica. Advances in ophthalmology · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flash electroretinogram responses were measured in normal subjects to different chromatic combinations of flashes and backgrounds. The amplitudes of the flash response components were measured at different flash strengths and could be described by a generalized Naka-Rushton function. The measurements were repeated at different background luminances to study adaptation effects. It was found that when flash strength and background luminance were expressed in photometric terms (cd s/m² and cd/m², respectively), then the responses were very similar for all chromatic combinations with the exception of the condition in which blue (peak wavelength 458 nm) was flashed upon an orange (peak wavelength 591 nm) background. We propose that in this condition, a second (possibly S-cone or rod-driven) mechanism intrudes. The negative response after the b-wave (here called "photopic negative response" or PhNR for all conditions) is thought to reflect ganglion cell activity and was also largest at this condition. Responses were measured to the 458 nm flash on 591 nm background and the reversed combination in a population of 39 normal subjects and 49 glaucoma patients. It was found that the PhNR amplitude was affected by glaucoma in all conditions. Other component parameters, reflecting responses and adaptation dynamics, were not altered. The best stimulus condition among the conditions used to separate the PhNR amplitude of normals and patients was a 1 cd s/m² 458 nm flash on a 10 cd/m² 591 nm background.
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