Evidence map›Paper›PMID 22227671›Full record

ArticleNature medicine2012

Dysregulation of immune homeostasis in autoimmune diseases.

Vijay K Kuchroo, Pamela S Ohashi, R Balfour Sartor, Carola G Vinuesa

Abstract read
PubMed Publisher
In one paragraph

Article in Nature medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. Immunoenhancing Effects of JejuPharmaceuticals (Basel, Switzerland) · 2025
    Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Cardiovascular Implications of Immune Disorders in Women.Circulation research · 2022 · on this map
    Review
  14. Review
  15. Article
  16. Bone Morphogenetic Proteins Shape TFrontiers in immunology · 2022
    Review
  17. Article
  18. Article
  19. Chronic Prostatitis and Pelvic Pain Syndrome: Another Autoimmune Disease?Archivum immunologiae et therapiae experimentalis · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Vijay K KuchrooCenter for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. vkuchroo@rics.bwh.harvard.edu
Pamela S Ohashi
R Balfour Sartor
Carola G Vinuesa
Australian National University · AUHarvard University · USUniversity of North Carolina at Chapel Hill · USUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adaptive ImmunityAutoimmune DiseasesGene-Environment InteractionGenetic Predisposition to DiseaseHomeostasisHumansImmunity, InnateMajor Histocompatibility ComplexPolymorphism, Single NucleotideT-Lymphocytes

Identifiers

PMID22227671
OpenAlexW1974666461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.