Evidence map›Paper›PMID 22227670›Full record

ArticleNature medicine2012

Unraveling the autoimmune translational research process layer by layer.

Richard S Blumberg, Bonnie Dittel, David Hafler, Matthias von Herrath, Frank O Nestle

Abstract read
In one paragraph

Article in Nature medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Targeting the MHC Ligandome by Use of TCR-Like Antibodies.Antibodies (Basel, Switzerland) · 2019
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Mapping the evolving definitions of translational research.Journal of clinical and translational science · 2017
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Richard S BlumbergDivision of Gastroenterology and Hepatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. rblumberg@partners.org
Bonnie Dittel
David Hafler
Matthias von Herrath
Frank O Nestle

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
Regulation of Mucosal LymphocytesR01DK051362 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Richard S Blumberg, Yu-Hwa Huang Blumberg · 1997 to 2026
$13.5M
INTESTINAL TRANSCYTOSIS OF IGG IN ADULT LIFER01DK053056 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BLUMBERG, RICHARD S · 1997 to 2021
$10.6M
MOLECULAR CHARACTERIZATION OF MUCOSAL LYMPHOCYTESR01DK044319 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Richard S Blumberg · 1992 to 2026
$10.4M
Endoplasmic reticulum stress and intestinal inflammationR01DK088199 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Richard S Blumberg · 2010 to 2026
$9.6M
Characterization of Mucosal LymphocytesR37DK044319 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BLUMBERG, RICHARD S · 2005 to 2014
$7.2M
Intestinal Immune Regulation by IgG and FcRnR56DK053056 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BLUMBERG, RICHARD S · 2017 to 2017
$100k
Department of HealthMedical Research Council G0601387Medical Research Council MR/J006742/1NIDDK NIH HHS DK34854NIDDK NIH HHS DK44319NIDDK NIH HHS DK51362NIDDK NIH HHS DK53056NIDDK NIH HHS DK88199NIDDK NIH HHS P30 DK034854NIDDK NIH HHS R01 DK044319NIDDK NIH HHS R01 DK051362NIDDK NIH HHS R01 DK053056NIDDK NIH HHS R01 DK088199NIDDK NIH HHS R37 DK044319NIDDK NIH HHS R56 DK053056Wellcome TrustWellcome Trust GR078173MA
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Translational Research, BiomedicalAutoimmune DiseasesDrug ApprovalGenome-Wide Association StudyHumansUnited StatesUnited States Food and Drug Administration

Identifiers

PMID22227670
PMCPMC4592149

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.