Evidence map›Paper›PMID 22227611›Full record

Trial reportPsychopharmacology2012

Sex differences in stimulus expectancy and pharmacologic effects of a moderate dose of alcohol on smoking lapse risk in a laboratory analogue study.

Christopher W Kahler, Jane Metrik, Nichea S Spillane, Adam M Leventhal, Sherry A McKee, Jennifer W Tidey, John E McGeary, Valerie S Knopik, Damaris J Rohsenow

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Breath holding duration and self-reported smoking abstinence intolerance as predictors of smoking lapse behavior in a laboratory analog task.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2013
    Trial
  7. Review
  8. Article
  9. Article
  10. Addiction-Related Outcomes of Nicotine and Alcohol Co-use: New Insights Following the Rise in Vaping.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Effect of doxazosin on stress reactivity and the ability to resist smoking.Journal of psychopharmacology (Oxford, England) · 2017
    Article
  15. An overview of alcohol and tobacco/nicotine interactions in the human laboratory.The American journal of drug and alcohol abuse · 2017
    Review
  16. Article
  17. Article
  18. Working Memory Moderates the Association Between Smoking Urge and Smoking Lapse Behavior After Alcohol Administration in a Laboratory Analogue Task.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christopher W KahlerCenter for Alcohol and Addiction Studies, Brown University, Box G-S121-5, Providence, RI 02912, USA. Christopher_Kahler@brown.edu
Jane Metrik
Nichea S Spillane
Adam M Leventhal
Sherry A McKee
Jennifer W Tidey
John E McGeary
Valerie S Knopik
Damaris J Rohsenow

Funding

Mechanisms Linkng Alcohol Use and Smoking Relapse RiskR01AA016978 · NIAAA · BROWN UNIVERSITY · PI KAHLER, CHRISTOPHER W. · 2008 to 2011
$2.1M
Marijuana's Acute Effects on Risk Taking, Sexual/HIV risk, and ImpulsivityR01DA021403 · NIDA · BROWN UNIVERSITY · PI METRIK, JANE · 2007 to 2009
$941k
Contextual risk factors for substance use in adolescent Reservation-Dwelling American IndiansK08DA029094 · NIDA · UNIVERSITY OF RHODE ISLAND · PI SPILLANE, NICHEA SOLOMON · 2010 to 2014
$862k
NIAAA NIH HHS R01 AA016978NIAAA NIH HHS R01AA016978NIDA NIH HHS K08 DA029094NIDA NIH HHS R01 DA021403
6 · The paper itself

Abstract

rationaleAlcohol use is often implicated in initial lapses to smoking during quit smoking attempts. Mechanisms explaining this association are unknown but could include (a) learned associations between drinking and smoking or (b) direct pharmacologic effects of alcohol.

objectivesIn a 2 (told alcohol vs. told placebo) × 2 (0.4 g/kg vs. 0.0 g/kg ethanol) between-subjects balanced placebo design, we examined instruction and beverage condition effects on smokers' ability to resist initiating smoking and whether these effects differed by sex.

methodsParticipants were 96 heavy alcohol drinkers, smoking 10-30 cigarettes per day. After 15 h of smoking abstinence, participants consumed either an alcoholic or a nonalcoholic beverage and 35 min later completed a smoking lapse task.

resultsOverall, neither instructions nor beverage contents influenced behavior on the smoking lapse task. However, the instruction condition had different effects in men and women. Women, but not men, were more likely to smoke and reported expecting greater satisfaction from smoking when they were told alcohol compared to told placebo. The effects of instruction condition on smoking behavior were not mediated by self-reported expected satisfaction from smoking.

conclusionsWomen may be more likely to choose to smoke after drinking moderate amounts of alcohol because of their expectations rather than the pharmacological effects of the alcohol.

Indexed as

AdultAlcohol DrinkingCentral Nervous System DepressantsDouble-Blind MethodEthanolFemaleHumansMaleMiddle AgedPersonal SatisfactionSex FactorsSmokingCentral Nervous System DepressantsEthanol

Identifiers

PMID22227611
PMCPMC3687530

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.