ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2012
Expression of a single-copy hsp-16.2 reporter predicts life span.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Heat tolerance and genetic adaptations in Caenorhabditis briggsae: insights from comparative studies with Caenorhabditis elegans.Genetics · 2025Article
- Beyond genes and environment: mapping biological stochasticity in aging.GeroScience · 2025Review
- PMFrontiers in public health · 2023Article
- Hijacking Cellular Stress Responses to Promote Lifespan.Frontiers in aging · 2022Review
- Shaping longevity early in life: developmental ROS and H3K4me3 set the clock.Cell cycle (Georgetown, Tex.) · 2021Article
- Gene-Environment Interactions and Stochastic Variations in the Gero-Exposome.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Distinct temporal actions of different types of unfolded protein responses during aging.Journal of cellular physiology · 2021Article
- Career Retrospective: Tom Johnson-Genetics, Genomics, Stress, Stochastic Variation, and Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Inhibition of mTOR decreases insoluble proteins burden by reducing translation in C. elegans.Biogerontology · 2021Article
- Nobiletin Delays Aging and Enhances Stress Resistance ofInternational journal of molecular sciences · 2020Article
- Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins.Nature communications · 2019Article
- Electrophysiological Measures of Aging Pharynx Function in C. elegans Reveal Enhanced Organ Functionality in Older, Long-lived Mutants.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- In vivo measurements reveal a single 5'-intron is sufficient to increase protein expression level in Caenorhabditis elegans.Scientific reports · 2019Article
- Transcriptome States Reflect Imaging of Aging States.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Caenorhabditis elegans Genes Affecting Interindividual Variation in Life-span Biomarker Gene Expression.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans.Nature communications · 2017Article
- Using measures of single-cell physiology and physiological state to understand organismic aging.Aging cell · 2016Review
- Article
- Methodological considerations for heat shock of the nematode Caenorhabditis elegans.Methods (San Diego, Calif.) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The level of green fluorescent protein expression from an hsp-16.2-based transcriptional reporter predicts life span and thermotolerance in Caenorhabditis elegans. The initial report used a high-copy number reporter integrated into chromosome IV. There was concern that the life-span prediction power of this reporter was not attributable solely to hsp-16.2 output. Specifically, prediction power could stem from disruption of some critical piece of chromatin on chromosome IV by the gpIs1 insertion, a linked mutation from the process used to create the reporter, or from an artifact of transgene regulation (multicopy transgenes are subject to regulation by C elegans chromatin surveillance machinery). Here we determine if the ability to predict life span and thermotolerance is specific to the gpIs1 insertion or a general property of hsp-16.2-based reporters. New single-copy hsp-16.2-based reporters predict life span and thermotolerance. We conclude that prediction power of hsp-16.2-based transcriptional reporters is not an artifact of any specific transgene configuration or chromatin surveillance mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.