ArticleSchizophrenia research2012
HPA axis function and symptoms in adolescents at clinical high risk for schizophrenia.
Article in Schizophrenia research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Clinical high risk for psychosis in children and adolescents: a systematic review.European child & adolescent psychiatry · 2018Pooled it
- Altered relationship between cortisol response to social stress and mediotemporal function during fear processing in people at clinical high risk for psychosis: a preliminary report.European archives of psychiatry and clinical neuroscience · 2022Trial
- Parvalbumin and anxiety across development in female offspring of the MAM neurodevelopmental model of schizophrenia.Journal of psychiatric research · 2026Article
- The cortisol axis and psychiatric disorders: an updated review.Pharmacological reports : PR · 2025Review
- Determination of Cortisol Levels in a Small Volume of Saliva of COVID-19-Recovering Patients During Treatment with Psychotropic Drugs.Biomedicines · 2025Article
- Abnormal cortisol profile during psychosocial stress among patients with schizophrenia in a Chinese population.Scientific reports · 2022Article
- The relationship between stress responding in family context and stress sensitivity with sleep dysfunction in individuals at clinical high-risk for psychosis.Journal of psychiatric research · 2022Article
- Equity in Mental Health Services for Youth at Clinical High Risk for Psychosis: Considering Marginalized Identities and Stressors.Evidence-based practice in child and adolescent mental health · 2022Article
- Cortisol as a Biomarker of Mental Disorder Severity.Journal of clinical medicine · 2021Review
- Emerging therapeutic targets for schizophrenia: a framework for novel treatment strategies for psychosis.Expert opinion on therapeutic targets · 2021Review
- The pathophysiological impact of stress on the dopamine system is dependent on the state of the critical period of vulnerability.Molecular psychiatry · 2020Article
- Subtyping schizophrenia based on symptomatology and cognition using a data driven approach.Psychiatry research. Neuroimaging · 2020Article
- A shared genetic contribution to breast cancer and schizophrenia.Nature communications · 2020Article
- Current challenges and possible future developments in personalized psychiatry with an emphasis on psychotic disorders.Heliyon · 2020Review
- Consistent Exposure to Psychosocial Stressors and Progressive Intolerance to Stress in Individuals at Clinical High Risk for Psychosis.Schizophrenia bulletin open · 2020Article
- Advances in clinical staging, early intervention, and the prevention of psychosis.F1000Research · 2019Review
- Attacking Heterogeneity in Schizophrenia by Deriving Clinical Subgroups From Widely Available Symptom Data.Schizophrenia bulletin · 2018Article
- Effects of early trauma on psychosis development in clinical high-risk individuals and stability of trauma assessment across studies: a review.Archives of psychology (Chicago, Ill.) · 2017Article
- Anxiety in youth at clinical high risk for psychosis.Early intervention in psychiatry · 2017Article
- The relationship between cannabis use and cortisol levels in youth at ultra high-risk for psychosis.Psychoneuroendocrinology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundStress sensitivity and HPA axis activity may be relevant to the development and expression of psychotic disorders. Cortisol secretion has been associated with positive symptoms both in patients with psychotic disorders and in young people at clinical risk for psychosis. Herein, we aimed to replicate these findings, to determine which positive symptoms may be associated with cortisol levels, and to explore any associations with affective symptoms and impaired stress tolerance.
methodsThirty-one clinical high risk patients were evaluated in cross-section for associations between salivary cortisol levels upon clinic entry at 11 am, demographic variables, and clinical symptoms.
resultsSalivary cortisol levels were unrelated to medication exposure or demographics, except for higher levels in the ten females studied. Salivary cortisol bore no relationship to overall positive symptom severity but was associated with anxiety, as well as with suspiciousness and impaired stress tolerance, which were themselves highly intercorrelated.
conclusionsCortisol secretion in the context of a putative novel social situation (i.e. clinic entry) may be a biological correlate of suspiciousness, impaired stress tolerance and affective symptoms in individuals vulnerable to developing psychosis. These associations are consistent with findings from experience sampling studies in individuals at risk for psychosis as well as basic studies of animal models of schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.