Evidence map›Paper›PMID 22226532›Full record

ArticleMethods in cell biology2012

Electrophysiological methods for Caenorhabditis elegans neurobiology.

Miriam B Goodman, Theodore H Lindsay, Shawn R Lockery, Janet E Richmond

Open access · greenAbstract read
In one paragraph

Article in Methods in cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Journal of biosciences · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Praziquantel activates a native cation current inFrontiers in parasitology · 2023
    Article
  8. Multisensory Integration inBrain sciences · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Novel Technological Advances in Functional Connectomics inJournal of developmental biology · 2019
    Review
  16. Article
  17. Neural Interactome: Interactive Simulation of a Neuronal System.Frontiers in computational neuroscience · 2019
    Article
  18. Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
    Review
  19. Genetic dissection of neuropeptide cell biology at high and low activity in a defined sensory neuron.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Miriam B GoodmanDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, USA.
Theodore H Lindsay
Shawn R Lockery
Janet E Richmond
University of Oregon · USStanford University · USUniversity of Illinois Chicago · US

Funding

Molecular Basis of Sensory Transduction in C. elegansR01NS047715 · NINDS · STANFORD UNIVERSITY · PI GOODMAN, MIRIAM B · 2004 to 2017
$4.9M
NEURONAL AND THEORETICAL ANALYSIS OF SPATIAL ORIENTATIONR01MH051383 · NIMH · UNIVERSITY OF OREGON · PI LOCKERY, SHAWN R · 1999 to 2016
$4.7M
Force Clamp Systems for Evaluation of MechanotransductionR01EB006745 · NIBIB · STANFORD UNIVERSITY · PI GOODMAN, MIRIAM B, PRUITT, BETH L · 2007 to 2014
$3.1M
The role of tomosyn in synaptic transmission.R01MH073156 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI RICHMOND, JANET E · 2006 to 2010
$2.0M
UNC-18 function in C. elegans synaptic transmissionR01NS041477 · NINDS · UNIVERSITY OF UTAH · PI RICHMOND, JANET E · 2002 to 2006
$1.2M
Neurogenetic analysis of value-based decision makingR21MH112105 · NIMH · UNIVERSITY OF OREGON · PI LOCKERY, SHAWN R · 2017 to 2018
$405k
NIBIB NIH HHS R01 EB006745NIMH NIH HHS R01 MH051383NIMH NIH HHS R01 MH073156NIMH NIH HHS R21 MH112105NINDS NIH HHS R01 NS041477NINDS NIH HHS R01 NS047715
6 · The paper itself

Abstract

Patch-clamp electrophysiology is a technique of choice for the biophysical analysis of the function of nerve, muscle, and synapse in Caenorhabditis elegans nematodes. Considerable technical progress has been made in C. elegans electrophysiology in the decade since the initial publication of this technique. Today, most, if not all, electrophysiological studies that can be done in larger animal preparations can also be done in C. elegans. This chapter has two main goals. The first is to present to a broad audience the many techniques available for patch-clamp analysis of neurons, muscles, and synapses in C. elegans. The second is to provide a methodological introduction to the techniques for patch clamping C. elegans neurons and body-wall muscles in vivo, including emerging methods for optogenetic stimulation coupled with postsynaptic recording. We also present samples of the cell-intrinsic and postsynaptic ionic currents that can be measured in C. elegans nerves and muscles.

Indexed as

Action PotentialsAdhesivesAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansElectrodesImmobilizationLightMicrodissectionMusclesNeurobiologyNeuronsPatch-Clamp TechniquesPhotic StimulationSynapsesSynaptic PotentialsAdhesives

Identifiers

PMID22226532
PMCPMC3959639
OpenAlexW2464736581

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.