ReviewComparative immunology, microbiology and infectious diseases2012
Adaptive immunity to Anaplasma pathogens and immune dysregulation: implications for bacterial persistence.
Review in Comparative immunology, microbiology and infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Haematology, serum biochemistry, innate and adaptive immune system responses to blood pathogen infections in cattle: A review.Parasitology research · 2026Review
- Acute infection with the U.S. isolate ofFrontiers in veterinary science · 2026Article
- Tissue-specific localization of tick-borne pathogens in ticks collected from camels in Kenya: insights into vector competence.Frontiers in cellular and infection microbiology · 2024Article
- Aetiologies of bacterial tick-borne febrile illnesses in humans in Africa: diagnostic limitations and the need for improvement.Frontiers in medicine · 2024Review
- Host-pathogen associations revealed by genotyping of European strains of Anaplasma phagocytophilum to describe natural endemic cycles.Parasites & vectors · 2023Article
- Epidemiology ofInternational journal for parasitology. Parasites and wildlife · 2023Article
- Comparative Study of the Use of Doxycycline and Oxytetracycline to Treat Anaplasmosis in Fattening Lambs.Animals : an open access journal from MDPI · 2022Article
- Role of NK-Like CD8Infection and immunity · 2022Article
- Epidemiological Study Related to the First Outbreak of Ovine Anaplasmosis in Spain.Animals : an open access journal from MDPI · 2021Article
- Tick host immunity: vector immunomodulation and acquired tick resistance.Trends in immunology · 2021Review
- Ticks and Tick-Borne Pathogens Associated with Dromedary Camels (Microorganisms · 2021Article
- Epidemiological and Clinicopathological Features ofFrontiers in veterinary science · 2021Review
- Immune Response to Tick-Borne Hemoparasites: Host Adaptive Immune Response Mechanisms as Potential Targets for Therapies and Vaccines.International journal of molecular sciences · 2020Review
- Disruption of VirB6 Paralogs in Anaplasma phagocytophilum Attenuates Its Growth.Journal of bacteriology · 2020Article
- Anaplasmosis Outbreak in Lambs: First Report Causing Carcass Condemnation.Animals : an open access journal from MDPI · 2020Article
- Zoonotic Tick-Borne Pathogens in Temperate and Cold Regions of Europe-A Review on the Prevalence in Domestic Animals.Frontiers in veterinary science · 2020Review
- Global Transcription Profiles ofFrontiers in veterinary science · 2020Article
- Diagnostic Tools for the Identification ofPathogens (Basel, Switzerland) · 2019Review
- VirB10 vaccination for protection against Anaplasma phagocytophilum.BMC microbiology · 2018Article
- A lifelong study of a pack Rhodesian ridgeback dogs reveals subclinical and clinical tick-borne Anaplasma phagocytophilum infections with possible reinfection or persistence.Parasites & vectors · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Anaplasma marginale is an obligate intraerythrocytic bacterium that infects ruminants, and notably causes severe economic losses in cattle worldwide. Anaplasma phagocytophilum infects neutrophils and causes disease in many mammals, including ruminants, dogs, cats, horses, and humans. Both bacteria cause persistent infection - infected cattle never clear A. marginale and A. phagocytophilum can also cause persistent infection in ruminants and other animals for several years. This review describes correlates of the protective immune response to these two pathogens as well as subversion and dysregulation of the immune response following infection that likely contribute to long-term persistence. I also compare the immune dysfunction observed with intraerythrocytic A. marginale to that observed in other models of chronic infection resulting in high antigen loads, including malaria, a disease caused by another intraerythrocytic pathogen.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.