ArticleBiophysical journal2012
Two-component coarse-grained molecular-dynamics model for the human erythrocyte membrane.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- A Computationally Efficient Viscoelastic Eukaryotic Cell Model.Annals of biomedical engineering · 2025Article
- Stomatocyte-discocyte-echinocyte transformations of erythrocyte modulated by membrane-cytoskeleton mechanical properties.Biophysical journal · 2025Article
- Two-component macrophage model for active phagocytosis with pseudopod formation.Biophysical journal · 2024Article
- In silico and in vitro study of the adhesion dynamics of erythrophagocytosis in sickle cell disease.Biophysical journal · 2023Article
- Circulating cell clusters aggravate the hemorheological abnormalities in COVID-19.Biophysical journal · 2022Article
- Multiphysics and multiscale modeling of microthrombosis in COVID-19.PLoS computational biology · 2022Article
- Recent Advances in Computational Modeling of Biomechanics and Biorheology of Red Blood Cells in Diabetes.Biomimetics (Basel, Switzerland) · 2022Article
- Computational investigation of blood cell transport in retinal microaneurysms.PLoS computational biology · 2022Article
- Article
- Computational modeling of biomechanics and biorheology of heated red blood cells.Biophysical journal · 2021Article
- Modeling of the axon plasma membrane structure and its effects on protein diffusion.PLoS computational biology · 2019Article
- Quantifying Shear-Induced Deformation and Detachment of Individual Adherent Sickle Red Blood Cells.Biophysical journal · 2019Article
- Synergistic Integration of Laboratory and Numerical Approaches in Studies of the Biomechanics of Diseased Red Blood Cells.Biosensors · 2018Review
- Cytoskeleton Remodeling Induces Membrane Stiffness and Stability Changes of Maturing Reticulocytes.Biophysical journal · 2018Article
- Investigation of red blood cell mechanical properties using AFM indentation and coarse-grained particle method.Biomedical engineering online · 2017Article
- Probing eukaryotic cell mechanics via mesoscopic simulations.PLoS computational biology · 2017Article
- Modeling of Biomechanics and Biorheology of Red Blood Cells in Type 2 Diabetes Mellitus.Biophysical journal · 2017Article
- Mesoscopic Adaptive Resolution Scheme toward Understanding of Interactions between Sickle Cell Fibers.Biophysical journal · 2017Article
- Computational Biomechanics of Human Red Blood Cells in Hematological Disorders.Journal of biomechanical engineering · 2017Review
- Antagonistic Behaviors of NMY-1 and NMY-2 Maintain Ring Channels in the C. elegans Gonad.Biophysical journal · 2016Article
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2 authors.
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Abstract
We present a two-component coarse-grained molecular-dynamics model for simulating the erythrocyte membrane. The proposed model possesses the key feature of combing the lipid bilayer and the erythrocyte cytoskeleton, thus showing both the fluidic behavior of the lipid bilayer and the elastic properties of the erythrocyte cytoskeleton. In this model, three types of coarse-grained particles are introduced to represent clusters of lipid molecules, actin junctions, and band-3 complexes, respectively. The proposed model facilitates simulations that span large length scales (approximately micrometers) and timescales (approximately milliseconds). By tuning the interaction potential parameters, we were able to control the diffusivity and bending rigidity of the membrane model. We studied the membrane under shearing and found that at a low shear strain rate, the developed shear stress was due mainly to the spectrin network, whereas the viscosity of the lipid bilayer contributed to the resulting shear stress at higher strain rates. In addition, we investigated the effects of a reduced spectrin network connectivity on the shear modulus of the membrane.
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