ArticleBiophysical journal2012
Lipid-protein interactions alter line tensions and domain size distributions in lung surfactant monolayers.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 0 citations in OpenAlex.
- Surfactant protein SP-B: one ring to rule the molecular and biophysical mechanisms of the pulmonary surfactant system.Biophysical reviews · 2025Review
- Surfactant Proteins SP-B and SP-C in Pulmonary Surfactant Monolayers: Physical Properties Controlled by Specific Protein-Lipid Interactions.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Biophysical analysis of gelatin and PLGA nanoparticle interactions with complex biomimetic lung surfactant models.RSC advances · 2022Article
- Article
- Spontaneous evolution of equilibrium morphology in phospholipid-cholesterol monolayers.Science advances · 2022Article
- Interactions of particulate matter and pulmonary surfactant: Implications for human health.Advances in colloid and interface science · 2020Review
- In vitro characterization and in vivo comparison of the pulmonary outcomes of Poractant alfa and Calsurf in ventilated preterm rabbits.PloS one · 2020Article
- Comparison of Line Tension Measurement Methods for Lipid Monolayers at Liquid-Liquid Coexistence.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Interactions between lipids and proteins are critical for organization of plasma membrane-ordered domains in tobacco BY-2 cells.Journal of experimental botany · 2018Article
- Interfacial curvature effects on the monolayer morphology and dynamics of a clinical lung surfactant.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Combined effect of synthetic protein, Mini-B, and cholesterol on a model lung surfactant mixture at the air-water interface.Biochimica et biophysica acta · 2016Article
- Low-dose AgNPs reduce lung mechanical function and innate immune defense in the absence of cellular toxicity.Nanotoxicology · 2016Article
- Phospholipid composition modulates carbon nanodiamond-induced alterations in phospholipid domain formation.Langmuir : the ACS journal of surfaces and colloids · 2015Article
- Visualizing monolayers with a water-soluble fluorophore to quantify adsorption, desorption, and the double layer.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Investigating the effect of particle size on pulmonary surfactant phase behavior.Biophysical journal · 2014Article
- Fetal and neonatal samples of a precursor surfactant protein B inversely related to gestational age.BMC pediatrics · 2013Article
- Delivery and performance of surfactant replacement therapies to treat pulmonary disorders.Therapeutic delivery · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
The size distribution of domains in phase-separated lung surfactant monolayers influences monolayer viscoelasticity and compressibility which, in turn, influence monolayer collapse and set the compression at which the minimum surface tension is reached. The surfactant-specific protein SP-B decreases the mean domain size and polydispersity as shown by fluorescence microscopy. From the images, the line tension and dipole density difference are determined by comparing the measured size distributions with a theory derived by minimizing the free energy associated with the domain energy and mixing entropy. We find that SP-B increases the line tension, dipole density difference, and the compressibility modulus at surface pressures up to the squeeze-out pressure. The increase in line tension due to SP-B indicates the protein avoids domain boundaries due to its solubility in the more fluid regions of the film.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.