ArticleBiophysical journal2012
A novel phase of compressed bilayers that models the prestalk transition state of membrane fusion.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Interaction of a short antimicrobial peptide on charged lipid bilayer: A case study on aurein 1.2 peptide.BBA advances · 2022Article
- Calculating Transition Energy Barriers and Characterizing Activation States for Steps of Fusion.Biophysical journal · 2016Article
- Process of inducing pores in membranes by melittin.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Review
- Energetics of stalk intermediates in membrane fusion are controlled by lipid composition.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Acyl-chain correlation in membrane fusion intermediates: x-ray diffraction from the rhombohedral lipid phase.Biophysical journal · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The force model of protein-mediated membrane fusion hypothesizes that fusion is driven by mechanical forces exerted on the membranes, but many details are unknown. Here, we investigated by x-ray diffraction the consequence of applying compressive force on a stack of membranes against the hydration barrier. We found that as the osmotic pressure increased, the lamellar phase transformed first to a new phase of tetragonal lattice (T-phase) over a narrow range of relative humidity, and then to a phase of rhombohedral lattice. The unit cell structure changed from parallel bilayers to a bent configuration with a point contact between adjacent bilayers and then to the stalk hemifusion configuration. The T-phase is discussed as a possible transition state in the membrane merging pathway of fusion. We estimate the work required to form the T-phase and the subsequent hemifusion-stalk-resembling R-phase. The work for the formation of a stalk is compatible with the energy estimated to be released by several SNARE complexes.
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Registered trials
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