ArticleBiophysical journal2012
Extracting surface activation time from the optically recorded action potential in three-dimensional myocardium.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Panoramic hyperspectral optical mapping of cardiac membrane potential and tissue type.Journal of biomedical optics · 2026Article
- A comprehensive framework for evaluation of high pacing frequency and arrhythmic optical mapping signals.Frontiers in physiology · 2023Article
- High resolution optical mapping of cardiac electrophysiology in pre-clinical models.Scientific data · 2022Article
- Circle Method for Robust Estimation of Local Conduction Velocity High-Density Maps From Optical Mapping Data: Characterization of Radiofrequency Ablation Sites.Frontiers in physiology · 2022Article
- A dataset of dual calcium and voltage optical mapping in healthy and hypertrophied murine hearts.Scientific data · 2021Article
- ElectroMap: High-throughput open-source software for analysis and mapping of cardiac electrophysiology.Scientific reports · 2019Article
- Examination of the Effects of Conduction Slowing on the Upstroke of Optically Recorded Action Potentials.Frontiers in physiology · 2019Article
- Human Atrial Fibrillation Drivers Resolved With Integrated Functional and Structural Imaging to Benefit Clinical Mapping.JACC. Clinical electrophysiology · 2018Article
- Tissue-Specific Optical Mapping Models of Swine Atria Informed by Optical Coherence Tomography.Biophysical journal · 2018Article
- Role of the Purkinje-Muscle Junction on the Ventricular Repolarization Heterogeneity in the Healthy and Ischemic Ovine Ventricular Myocardium.Frontiers in physiology · 2018Article
- Evaluation of excitation propagation in the rabbit heart: optical mapping and transmural microelectrode recordings.PloS one · 2015Article
- Influence of the Purkinje-muscle junction on transmural repolarization heterogeneity.Cardiovascular research · 2014Article
- Toward microendoscopy-inspired cardiac optogenetics in vivo: technical overview and perspective.Journal of biomedical optics · 2014Review
- Diastolic field stimulation: the role of shock duration in epicardial activation and propagation.Biophysical journal · 2013Article
- Transfer of Kv3.1 voltage sensor features to the isolated Ci-VSP voltage-sensing domain.Biophysical journal · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Optical mapping has become an indispensible tool for studying cardiac electrical activity. However, due to the three-dimensional nature of the optical signal, the optical upstroke is significantly longer than the electrical upstroke. This raises the issue of how to accurately determine the activation time on the epicardial surface. The purpose of this study was to establish a link between the optical upstroke and exact surface activation time using computer simulations, with subsequent validation by a combination of microelectrode recordings and optical mapping experiments. To simulate wave propagation and associated optical signals, we used a hybrid electro-optical model. We found that the time of the surface electrical activation (t(E)) within the accuracy of our simulations coincided with the maximal slope of the optical upstroke (t(F)*) for a broad range of optical attenuation lengths. This was not the case when the activation time was determined at 50% amplitude (t(F50)) of the optical upstroke. The validation experiments were conducted in isolated Langendorff-perfused rat hearts and coronary-perfused pig left ventricles stained with either di-4-ANEPPS or the near-infrared dye di-4-ANBDQBS. We found that t(F)* was a more accurate measure of t(E) than was t(F50) in all experimental settings tested (P = 0.0002). Using t(F)* instead of t(F50) produced the most significant improvement in measurements of the conduction anisotropy and the transmural conduction time in pig ventricles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.