ArticlePharmacognosy research2012
Antidepressant-like effects of young green barley leaf (Hordeum vulgare L.) in the mouse forced swimming test.
Article in Pharmacognosy research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 62 citations in OpenAlex.
- Lachnospiraceae-Derived Extracellular Vesicles Mediate the Cardioprotective Effects of Barley Leaf in Myocardial Infarction by Improving Intestinal Stem Cell Function.Journal of extracellular vesicles · 2026Article
- Lactobacillus plantarum-derived extracellular vesicles from dietary barley leaf supplementation attenuate Citrobacter rodentium infection and intestinal inflammation.Journal of nanobiotechnology · 2025Article
- Impact of Six Extraction Methods on Molecular Composition and Antioxidant Activity of Polysaccharides from Young Hulless Barley Leaves.Foods (Basel, Switzerland) · 2023Article
- Barley Leaf AmelioratesNutrients · 2022Article
- Chemical Characterization and In Vitro Anti-Cancer Activities of a Hot Water Soluble Polysaccharide from Hulless Barley Grass.Foods (Basel, Switzerland) · 2022Article
- Metabolic Profiling Analysis Reveals the Potential Contribution of Barley Sprouts against Oxidative Stress and Related Liver Cell Damage in Habitual Alcohol Drinkers.Antioxidants (Basel, Switzerland) · 2021Article
- Attitudes Toward Psychological Disorders and Alternative Medicine in Saudi Participants.Frontiers in psychiatry · 2021Article
- Acute Oral Toxicity and Genotoxicity of Polysaccharide Fraction from Young Barley Leaves (Foods (Basel, Switzerland) · 2020Article
- Bioactivity evaluations of leaf extract fractions from young barley grass and correlation with their phytochemical profiles.BMC complementary medicine and therapies · 2020Article
- Influence of Abiotic Stress Factors on the Antioxidant Properties and Polyphenols Profile Composition of Green Barley (International journal of molecular sciences · 2020Article
- Bifidogenic and butyrogenic effects of young barely leaf extract in an in vitro human colonic microbiota model.AMB Express · 2019Article
- Using Goat's Milk, Barley Flour, Honey, and Probiotic to Manufacture of Functional Dairy Product.Probiotics and antimicrobial proteins · 2018Article
- Preventive and Therapeutic Role of Functional Ingredients of Barley Grass for Chronic Diseases in Human Beings.Oxidative medicine and cellular longevity · 2018Review
- Antioxidant, anti-inflammatory and anti-septic potential of phenolic acids and flavonoid fractions isolated from Lolium multiflorum.Pharmaceutical biology · 2017Article
- Protective effect of young green barley leaf (Hordeum vulgare L.) on restraint stress-induced decrease in hippocampal brain-derived neurotrophic factor in mice.Pharmacognosy magazine · 2015Article
- Subchronic Arsenic Exposure Induces Anxiety-Like Behaviors in Normal Mice and Enhances Depression-Like Behaviors in the Chemically Induced Mouse Model of Depression.BioMed research international · 2015Article
- Effects of young barley leaf powder on gastrointestinal functions in rats and its efficacy-related physicochemical properties.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Behavioral and neuronal biochemical possible effects in experimental induced chronic mild stress in male albino rats under the effect of oral barley administration in comparison to venlafaxine.International journal of physiology, pathophysiology and pharmacology · 2013Article
- Insoluble fiber in young barley leaf suppresses the increment of postprandial blood glucose level by increasing the digesta viscosity.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Room-temperature super-extraction system (RTSES) optimizes the anxiolytic- and antidepressant-like behavioural effects of traditional Xiao-Yao-San in mice.Chinese medicine · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundYoung green barley leaf is one of the richest sources of antioxidants and has been widely consumed for health management in Japan. In this study, we examined whether oral administration of young green barley leaf has an antidepressant effect on the forced swimming test in mice. MATERIALS AND
methodsMice were individually forced to swim in an open cylindrical container, one hour after oral administration of young green barley leaf (400 or 1000 mg / kg) or imipramine (100 mg / kg). Expression of mRNA for nerve growth factor (NGF), brain-derived neurotrophic factor, and glucocorticoid receptor in the brain was analyzed using real-time quantitative polymerase chain reaction (PCR).
resultsThere was a significant antidepressant-like effect in the forced swimming test; both 400 and 1000 mg / kg young green barley leaves, as well as the positive control imipramine (100 mg / kg), reduced the immobility duration compared to the vehicle group. The expression of mRNA for NGF detected in the hippocampus immediately after the last swimming test was higher than that in the non-swimming group (Nil). Oral administration of imipramine suppressed this increase to the level of the Nil group. Young green barley leaf (400 and 1000 mg / kg) also showed a moderate decrease in the expression of mRNA for NGF, in a dose-dependent manner.
conclusionOral administration of young green barley leaf is able to produce an antidepressant-like effect in the forced swimming test. Consequently it is possible that the antidepressant-like effects of the young green barley leaf are, at least in part, mediated by an inhibition of the increase in the hippocampus levels of NGF.
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