ArticleJournal of young pharmacists : JYP2011
Oxidative stress induced by fluoroquinolones on treatment for complicated urinary tract infections in Indian patients.
Article in Journal of young pharmacists : JYP, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 84 citations in OpenAlex.
- Evaluation of the protective effect of quercetin and luteolin against ciprofloxacin- and chloramphenicol-induced oxidative stress in blood cells and their impact on the microbiological activity.Frontiers in pharmacology · 2025Article
- Metabolic response of Klebsiella oxytoca to ciprofloxacin exposure: a metabolomics approach.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Antioxidant Functions of Vitamin D and CYP11A1-Derived Vitamin D, Tachysterol, and Lumisterol Metabolites: Mechanisms, Clinical Implications, and Future Directions.Antioxidants (Basel, Switzerland) · 2024Review
- Modulatory effect of ciprofloxacin, a broad spectrum antibacterial drug, on mPT pore using rat model with estradiol benzoate-induced endometrial hyperplasia.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Immuno-antioxidative reno-modulatory effectiveness of Echinacea purpurea extract against bifenthrin-induced renal poisoning.Scientific reports · 2024Article
- Nephroprotective effect of vitamin D Against Levofloxacin-induced renal injury: an observational study.Journal of medicine and life · 2023Article
- Increased expression of glutathione peroxidase 3 prevents tendinopathy by suppressing oxidative stress.Frontiers in pharmacology · 2023Article
- A New Criterion for Fluoroquinolone-Associated Disability Diagnosis: Functional Gastrointestinal Disorders.Medicina (Kaunas, Lithuania) · 2021Article
- Ecotoxicological effects and accumulation of ciprofloxacin in Eichhornia crassipes under hydroponic conditions.Environmental science and pollution research international · 2019Article
- Effect of bifenthrin on oxidative stress parameters in the liver, kidneys, and lungs of rats.Environmental science and pollution research international · 2019Article
- Lomefloxacin Induces Oxidative Stress and Apoptosis in COLO829 Melanoma Cells.International journal of molecular sciences · 2017Article
- Antioxidative/oxidative effects and retarding osteoconductivity of ciprofloxacin-loaded porous polyvinyl alcohol/bioactive glass hybrid.Medical & biological engineering & computing · 2017Article
- Treatment of the Fluoroquinolone-Associated Disability: The Pathobiochemical Implications.Oxidative medicine and cellular longevity · 2017Review
- Riboflavin along with antibiotics balances reactive oxygen species and inflammatory cytokines and controlsJournal of inflammation (London, England) · 2016Article
- Influence of Moxifloxacin on Hepatic Redox Status and Plasma Biomarkers of Hepatotoxicity and Nephrotoxicity in Rat.Biochemistry research international · 2015Article
- Effects of repeated oral administration of pazufloxacin mesylate and meloxicam on the antioxidant status in rabbits.Journal of the American Association for Laboratory Animal Science : JAALAS · 2014Article
- Dietary Flaxseed in Non-Small Cell Lung Cancer Patients Receiving Chemoradiation.Journal of pulmonary & respiratory medicine · 2013Article
- Levofloxacin induces erythrocyte contraction leading to red cell death.Drug target insightsArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study is to examine the oxidative stress in patients on fluoroquinolones (ciprofloxacin, levofloxacin, gatifloxacin) therapy for complicated urinary tract infections and to correlate with plasma concentrations at different time intervals. Superoxide dismutase (SOD), glutathione, plasma antioxidant status and lipid peroxides were evaluated in 52 patients on different dosage regimens up to 5 days. There is significant and gradual elevation of lipid peroxide levels in patients on ciprofloxacin (3.6 ± 0.34 nmol/ml to 6.2 ± 0.94 nmol/ml) and levofloxacin (3.5 ± 0.84 nmol/ml to 5.1 ± 0.28 nmol/ml) dosage regimen but not with gatifloxacin (3.5 ± 0.84 nmol/ml to 3.74 ± 0.17 nmol.ml). There was substantial depletion in both SOD and glutathione levels particularly with ciprofloxacin. On the 5(th) day of treatment, plasma antioxidant status decreased by 77.6% %, 50.5%, 7.56% for ciprofloxacin, levofloxacin and gatifloxacin respectively. In conclusion ciprofloxacin and levofloxacin induce more reactive oxygen species that lead to cell damage than gatifloxacin irrespective of their concentrations in patient population.
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