Evidence map›Paper›PMID 22223675›Full record

ReviewDevelopment (Cambridge, England)2012

Cilia in vertebrate development and disease.

Edwin C Oh, Nicholas Katsanis

Open access · bronzeAbstract readReview
In one paragraph

Review in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 163 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Gene therapy rescues olfactory perception in a clinically relevant ciliopathy model of Bardet-Biedl syndrome.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  16. Hypothalamic primary cilium: A hub for metabolic homeostasis.Experimental & molecular medicine · 2021
    Review
  17. Investigating Primary Cilia during Peripheral Nervous System Formation.International journal of molecular sciences · 2021
    Article
  18. Article
  19. Primary cilia biogenesis and associated retinal ciliopathies.Seminars in cell & developmental biology · 2021
    Review
  20. Primary cilia safeguard cortical neurons in neonatal mouse forebrain from environmental stress-induced dendritic degeneration.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Edwin C OhCenter for Human Disease Modeling, Department of Cell Biology, Duke University, Durham NC 27710, USA. Edwin.oh@duke.edu
Nicholas Katsanis
Duke University · US

Funding

Molecular Genetics of BBSR01HD042601 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI DAVIS, ERICA ELLEN · 2003 to 2023
$8.2M
Genetic and Functional Studies of Human Ciliary SyndromesR01DK072301 · NIDDK · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI DAVIS, ERICA ELLEN · 2005 to 2022
$7.2M
The Role of Basa Bodies in Wnt SignalingR01DK075972 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI KATSANIS, NICHOLAS · 2007 to 2015
$3.1M
NICHD NIH HHS R01 HD042601NIDDK NIH HHS R01 DK072301NIDDK NIH HHS R01 DK075972
6 · The paper itself

Abstract

Through the combined study of model organisms, cell biology, cell signaling and medical genetics we have significantly increased our understanding of the structure and functions of the vertebrate cilium. This ancient organelle has now emerged as a crucial component of certain signaling and sensory perception pathways in both developmental and homeostatic contexts. Here, we provide a snapshot of the structure, function and distribution of the vertebrate cilium and of the pathologies that are associated with its dysfunction.

Indexed as

DiseaseAnimalsCiliaHedgehog ProteinsHomeostasisHumansMechanoreceptorsMiceMorphogenesisRatsSignal TransductionWnt ProteinsHedgehog ProteinsWnt Proteins

Identifiers

PMID22223675
PMCPMC3275291
OpenAlexW2130178991

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.