ArticleInflammatory bowel diseases2012
Heligmosomoides polygyrus abrogates antigen-specific gut injury in a murine model of inflammatory bowel disease.
Article in Inflammatory bowel diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Helminths in alternative therapeutics of inflammatory bowel disease.Intestinal research · 2025Review
- Targeting gut microbiota and metabolism profiles with coated sodium butyrate to ameliorate high-energy and low-protein diet-induced intestinal barrier dysfunction in laying hens.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Intestinal Helminth Infection Impairs Oral and Parenteral Vaccine Efficacy.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Mitigation ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Experimental colonization with Blastocystis ST4 is associated with protective immune responses and modulation of gut microbiome in a DSS-induced colitis mouse model.Cellular and molecular life sciences : CMLS · 2022Article
- Oral delivery of a functional algal-expressed TGF-β mimic halts colitis in a murine DSS model.Journal of biotechnology · 2021Article
- Article
- Preventive and therapeutic effects of Trichinella spiralis adult extracts on allergic inflammation in an experimental asthma mouse model.Parasites & vectors · 2019Article
- Hookworm-Derived Metabolites Suppress Pathology in a Mouse Model of Colitis and Inhibit Secretion of Key Inflammatory Cytokines in Primary Human Leukocytes.Infection and immunity · 2019Article
- Helminth Therapy: Advances in the use of Parasitic Worms Against Inflammatory Bowel Diseases and its Challenges.Helminthologia · 2018Article
- Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer.PLoS pathogens · 2017Article
- Therapeutic potential of helminths in autoimmune diseases: helminth-derived immune-regulators and immune balance.Parasitology research · 2017Review
- Helminths in the gastrointestinal tract as modulators of immunity and pathology.American journal of physiology. Gastrointestinal and liver physiology · 2017Review
- Regulation of type 2 diabetes by helminth-induced Th2 immune response.The Journal of veterinary medical science · 2017Article
- Linking the Microbiota, Chronic Disease, and the Immune System.Trends in endocrinology and metabolism: TEM · 2016Review
- Therapeutic potential of recombinant cystatin from Schistosoma japonicum in TNBS-induced experimental colitis of mice.Parasites & vectors · 2016Article
- Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins.BioMed research international · 2015Article
- Excretory/secretory products from Trichinella spiralis adult worms ameliorate DSS-induced colitis in mice.PloS one · 2014Article
- Translatability of helminth therapy in inflammatory bowel diseases.International journal for parasitology · 2013Review
- Helminth infections and host immune regulation.Clinical microbiology reviews · 2012Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDeveloping countries have a low incidence of inflammatory bowel disease (IBD), perhaps prevented by the high prevalence of helminth infections and other alterations in intestinal flora and fauna. Helminth infections prevent colitis in various murine models of IBD. IBD may be driven by an aberrant immune response to luminal antigen(s).
methodsWe developed a murine model of IBD in which gut injury was induced by a specific antigen to better simulate the IBD disease process and to determine if helminth infections could abolish gut injury induced by an orally administered antigen. The model features pan-enterocolitis triggered by feeding ovalbumin (OVA).
resultsThe intestinal inflammation is antigen-specific and generates interleukin (IL)-17 and interferon-gamma (IFN-γ), but not IL-4. Full expression of the disease required T cells with defective capacity to make IL-10 and treatment with a noninjurious, low dose of a nonsteroidal antiinflammatory drug. Exposure to Heligmosomoides polygyrus abrogated this antigen-induced gut injury. H. polygyrus colonization induced Foxp3(+) T regulatory cells (Tregs) and mucosal production of IL-10 from non-T cells. Lamina propria mononuclear cells from H. polygyrus-infected mice released less IL-17 and IFN-γ constitutively and when stimulated with OVA or anti-CD3/CD28 monoclonal antibodies.
conclusionsWe developed a murine IBD model featuring antigen-specific enterocolitis and demonstrate for the first time that gut inflammation induced by an antigen could be abrogated by H. polygyrus infection. Protection was associated with suppressed IL-17 and IFN-γ production, induction of Foxp3(+) Tregs, and elevated secretion of non-T-cell-derived IL-10, all of which could be part of the protective processes.
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