ArticleJournal of tissue engineering and regenerative medicine2013
Hydrogel surfaces to promote attachment and spreading of endothelial progenitor cells.
Article in Journal of tissue engineering and regenerative medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
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Who cites it
23 citing papers in PubMed, 75 citations in OpenAlex.
- Tannic Acid-Enhanced Gelatin-Based Composite Hydrogel as a Candidate for Canine Periodontal Regeneration.Gels (Basel, Switzerland) · 2025Article
- The mechanisms and applications of endothelial progenitor cell therapy in the treatment of intracranial aneurysm.Journal of translational medicine · 2025Review
- Heparin Immobilization Enhances Hemocompatibility, Re-Endothelization, and Angiogenesis of Decellularized Liver Scaffolds.International journal of molecular sciences · 2024Article
- Endothelial progenitor cells for fabrication of engineered vascular units and angiogenesis induction.Cell proliferation · 2024Review
- Modulation of Methacrylated Hyaluronic Acid Hydrogels Enables Their Use as 3D Cultured Model.Gels (Basel, Switzerland) · 2023Article
- Re-Endothelialization of Decellularized Liver Scaffolds: A Step for Bioengineered Liver Transplantation.Frontiers in bioengineering and biotechnology · 2022Review
- MMP-sensitive PEG hydrogel modified with RGD promotes bFGF, VEGF and EPC-mediated angiogenesis.Experimental and therapeutic medicine · 2019Article
- Synthesis and characterization of photocrosslinkable hydrogels from bovine skin gelatin.RSC advances · 2019Article
- Shape Memory Polymers Containing Higher Acrylate Content Display Increased Endothelial Cell Attachment.Polymers · 2017Article
- Evaluation of late outgrowth endothelial progenitor cell and umbilical vein endothelial cell responses to thromboresistant collagen-mimetic hydrogels.Journal of biomedical materials research. Part A · 2017Article
- Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.Journal of molecular and cellular cardiology · 2016Article
- Systematic evaluation of natural scaffolds in cutaneous wound healing.Journal of materials chemistry. B · 2015Article
- Functionalizable hydrogel microparticles of tunable size and stiffness for soft-tissue filler applications.Acta biomaterialia · 2014Article
- Gradient static-strain stimulation in a microfluidic chip for 3D cellular alignment.Lab on a chip · 2014Article
- 25th anniversary article: Rational design and applications of hydrogels in regenerative medicine.Advanced materials (Deerfield Beach, Fla.) · 2014Review
- Chemical sintering generates uniform porous hyaluronic acid hydrogels.Acta biomaterialia · 2014Article
- Elastomeric Recombinant Protein-based Biomaterials.Biochemical engineering journal · 2013Article
- Amniotic fluid-derived stem cells for cardiovascular tissue engineering applications.Tissue engineering. Part B, Reviews · 2013Review
- Bacteria-surface interactions.Soft matter · 2013Article
- Synthesis and characterization of hybrid hyaluronic acid-gelatin hydrogels.Biomacromolecules · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Endothelialization of artificial vascular grafts is a challenging process in cardiovascular tissue engineering. Functionalized biomaterials could be promising candidates to promote endothelialization in repair of cardiovascular injuries. The purpose of this study was to synthesize hyaluronic acid (HA) and heparin-based hydrogels that could promote adhesion and spreading of endothelial progenitor cells (EPCs). We report that the addition of heparin into HA-based hydrogels provides an attractive surface for EPCs promoting spreading and the formation of an endothelial monolayer on the hydrogel surface. To increase EPC adhesion and spreading, we covalently immobilized CD34 antibody (Ab) on HA-heparin hydrogels, using standard EDC/NHS amine-coupling strategies. We found that EPC adhesion and spreading on CD34 Ab-immobilized HA-heparin hydrogels was significantly higher than their non-modified analogues. Once adhered, EPCs spread and formed an endothelial layer on both non-modified and CD34 Ab-modified HA-heparin hydrogels after 3 days of culture. We did not observe significant adhesion and spreading when heparin was not included in the control hydrogels. In addition to EPCs, we also used human umbilical cord vein endothelial cells (HUVECs), which adhered and spread on HA-heparin hydrogels. Macrophages exhibited significantly less adhesion compared to EPCs on the same hydrogels. This composite material could possibly be used to develop surface coatings for artificial cardiovascular implants, due to its specificity for EPC and endothelial cells on an otherwise non-thrombogenic surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.