ReviewAIDS and behavior2012
Are we missing the importance of missing values in HIV prevention randomized clinical trials? Review and recommendations.
Review in AIDS and behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Debridement of diabetic foot ulcers: public health and clinical implications - a systematic review, meta-analysis, and meta-regression.BMJ surgery, interventions, & health technologies · 2022Pooled it
- Analytical methods used in estimating the prevalence of HIV/AIDS from demographic and cross-sectional surveys with missing data: a systematic review.BMC medical research methodology · 2020Pooled it
- The use of web-based diaries in sexual risk behaviour research: a systematic review.Sexually transmitted infections · 2014Pooled it
- Effectiveness of Circle of Life, an HIV-preventive intervention for American Indian middle school youths: a group randomized trial in a Northern Plains tribe.American journal of public health · 2014Trial
- smdi: an R package to perform structural missing data investigations on partially observed confounders in real-world evidence studies.JAMIA open · 2024Article
- A study on the correlation between family dynamic factors and depression in adolescents.Frontiers in psychiatry · 2022Article
- Comparative effects of telephone versus in-office behavioral counseling to improve HIV treatment outcomes among people living with HIV in a rural setting.Translational behavioral medicine · 2021Article
- Multiple Imputation for Incomplete Data in Environmental Epidemiology Research.Current environmental health reports · 2019Review
- Accounting for non-response bias using participation incentives and survey design: An application using gift vouchers.Economics letters · 2018Article
- Principled Approaches to Missing Data in Epidemiologic Studies.American journal of epidemiology · 2018Article
- Investigating tangible and mental resources as predictors of perceived household food insecurity during pregnancy among women in a South African birth cohort study.Social science & medicine (1982) · 2017Article
- Diminishing Perceived Threat of AIDS and Increasing Sexual Risks of HIV Among Men Who Have Sex with Men, 1997-2015.Archives of sexual behavior · 2017Article
- Multiple Imputation in Three or More Stages.Journal of statistical planning and inference · 2016Article
- Latent Class Analysis of Incomplete Data via an Entropy-Based Criterion.Statistical methodology · 2016Article
- An Audit of Protocol Deviations Submitted to an Institutional Ethics Committee of a Tertiary Care Hospital.PloS one · 2016Observational
- Viral suppression and antiretroviral medication adherence among alcohol using HIV-positive adults.International journal of behavioral medicine · 2014Article
- Latent class regression: inference and estimation with two-stage multiple imputation.Biometrical journal. Biometrische Zeitschrift · 2013Article
- Bringing it home: community survey of HIV risks to primary sex partners of men and women in alcohol-serving establishments in Cape Town, South Africa.Sexually transmitted infections · 2013Article
- Mi??ing data: should we c?re?American journal of public health · 2013Article
- Factors associated with study attrition among HIV-infected risky drinkers in St. Petersburg, Russia.HIV clinical trialsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Missing data in HIV prevention trials is a common complication to interpreting outcomes. Even a small proportion of missing values in randomized trials can cause bias, inefficiency and loss of power. We examined the extent of missing data and methods in which HIV prevention randomized clinical trials (RCT) have managed missing values. We used a database maintained by the HIV/AIDS Prevention Research Synthesis (PRS) Project at the Centers for Disease Control and Prevention (CDC) to identify related trials for our review. The PRS cumulative database was searched on June 15, 2010 and all citations that met the following criteria were retrieved: All RCTs which reported HIV/STD/HBV/HCV behavioral interventions with a biological outcome from 2005 to present. Out of the 57 intervention trials identified, all had some level of missing values. We found that the average missing values per study ranged between 3 and 97%. Averaging over all studies the percent of missing values was 26%. None of the studies reported any assumptions for managing missing data in their RCTs. Under some relaxed assumptions discussed below, we expect only 12% of studies to report unbiased results. There is a need for more detailed and thoughtful consideration of the missing data problem in HIV prevention trials. In the current state of managing missing data we risk major biases in interpretations. Several viable alternatives are available for improving the internal validity of RCTs by managing missing data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.