Evidence map›Paper›PMID 22223213›Full record

ReviewCirculation research2012

Inflammation, endoplasmic reticulum stress, autophagy, and the monocyte chemoattractant protein-1/CCR2 pathway.

Pappachan E Kolattukudy, Jianli Niu

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Circulation research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 2 pooled it
18.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 2 syntheses or guidelines pooled it, 241 citations in OpenAlex.

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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Pappachan E KolattukudyBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA. pk@ucf.edu
Jianli Niu
University of Central Florida · US

Funding

MCP-1 induced gene expression in cardiovascular diseaseR01HL069458 · NHLBI · UNIVERSITY OF CENTRAL FLORIDA · PI KOLATTUKUDY, PAPPACHAN · 2002 to 2005
$1.4M
MCPIP, a novel transcription factor in the development of heart failureR56HL069458 · NHLBI · UNIVERSITY OF CENTRAL FLORIDA · PI KOLATTUKUDY, PAPPACHAN KOLATTUKUDY · 2009 to 2009
$355k
NHLBI NIH HHS HL-69458NHLBI NIH HHS R01 HL069458NHLBI NIH HHS R56 HL069458
6 · The paper itself

Abstract

Numerous inflammatory cytokines have been implicated in the pathogenesis of cardiovascular diseases. Monocyte chemoattractant protein (MCP)-1/CCL2 is expressed by mainly inflammatory cells and stromal cells such as endothelial cells, and its expression is upregulated after proinflammatory stimuli and tissue injury. MCP-1 can function as a traditional chemotactic cytokine and also regulates gene transcription. The recently discovered novel zinc-finger protein, called MCPIP (MCP-1-induced protein), initiates a series of signaling events that causes oxidative and endoplasmic reticulum (ER) stress, leading to autophagy that can result in cell death or differentiation, depending on the cellular context. After a brief review of the basic processes involved in inflammation, ER stress, and autophagy, the recently elucidated role of MCP-1 and MCPIP in inflammatory diseases is reviewed. MCPIP was found to be able to control inflammatory response by inhibition of nuclear factor-κB activation through its deubiquitinase activity or by degradation of mRNA encoding a set of inflammatory cytokines through its RNase activity. The potential inclusion of such a novel deubiquitinase in the emerging anti-inflammatory strategies for the treatment of inflammation-related diseases such as cardiovascular diseases and type 2 diabetes is briefly discussed.

Indexed as

AutophagyCardiovascular DiseasesChemokine CCL2Endoplasmic ReticulumHumansInflammationReceptors, CCR2Signal TransductionStress, PhysiologicalChemokine CCL2Receptors, CCR2

Identifiers

PMID22223213
PMCPMC3265021
OpenAlexW2063932784

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.