ReviewCellular and molecular life sciences : CMLS2012
Chromosome instability and deregulated proliferation: an unavoidable duo.
Review in Cellular and molecular life sciences : CMLS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Modeling and targeting general and chromosome-specific aneuploidy in cancer.Genes & development · 2025Review
- Photobiomodulation by infrared radiation on hallmarks of cancer.Lasers in medical science · 2025Review
- Increased Tumor Intrinsic Growth Potential and Decreased Immune Function Orchestrate the Progression of Lung Adenocarcinoma.Frontiers in immunology · 2022Article
- Potential Roles of the Retinoblastoma Protein in Regulating Genome Editing.Frontiers in cell and developmental biology · 2018Review
- The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts.International journal of molecular sciences · 2017Review
- Residual expression of SMYD2 and SMYD3 is associated with the acquisition of complex karyotype in chronic lymphocytic leukemia.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease.Nature reviews. Nephrology · 2015Review
- Naturally occurring reoviruses for human cancer therapy.BMB reports · 2015Review
- Replicating poxviruses for human cancer therapy.Journal of microbiology (Seoul, Korea) · 2015Review
- Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer.Cancer research · 2014Article
- Whole chromosome instability resulting from the synergistic effects of pRB and p53 inactivation.Oncogene · 2014Article
- Multi-layered cancer chromosomal instability phenotype.Frontiers in oncology · 2013Review
- Taxane benefit in breast cancer--a role for grade and chromosomal stability.Nature reviews. Clinical oncology · 2013Review
- Aneuploidy in health, disease, and aging.The Journal of cell biology · 2013Review
- A double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instability.Frontiers in oncology · 2013Article
- Retinal horizontal cells lacking Rb1 sustain persistent DNA damage and survive as polyploid giant cells.Molecular biology of the cell · 2012Article
- Transforming fusions of FGFR and TACC genes in human glioblastoma.Science (New York, N.Y.) · 2012Article
- Unbalanced replication as a major source of genetic instability in cancer cells.American journal of blood research · 2012Article
- Implications of aneuploidy for stem cell biology and brain therapeutics.Frontiers in cellular neuroscience · 2012Article
- Genomic instability and eye diseases.Advances in ophthalmology practice and researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The concept that aneuploidy is a characteristic of malignant cells has long been known; however, the idea that aneuploidy is an active contributor to tumorigenesis, as opposed to being an associated phenotype, is more recent in its evolution. At the same time, we are seeing the emergence of novel roles for tumor suppressor genes and oncogenes in genome stability. These include the adenomatous polyposis coli gene (APC), p53, the retinoblastoma susceptibility gene (RB1), and Ras. Originally, many of these genes were thought to be tumor suppressive or oncogenic solely because of their role in proliferative control. Because of the frequency with which they are disrupted in cancer, chromosome instability caused by their dysfunction may be more central to tumorigenesis than previously thought. Therefore, this review will highlight how the proper function of cell cycle regulatory genes contributes to the maintenance of genome stability, and how their mutation in cancer obligatorily connects proliferation and chromosome instability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.