ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
Angiotensin II induces tumor necrosis factor-α expression and release from cultured human podocytes.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Renin angiotensin system-induced muscle wasting: putative mechanisms and implications for clinicians.Molecular and cellular biochemistry · 2025Review
- Angiotensin-II drives changes in microglia-vascular interactions in rats with heart failure.Communications biology · 2024Article
- Responses to Ang II (Angiotensin II), Salt Intake, and Lipopolysaccharide Reveal the Diverse Actions of TNF-α (Tumor Necrosis Factor-α) on Blood Pressure and Renal Function.Hypertension (Dallas, Tex. : 1979) · 2022Review
- Mechanisms of podocyte injury and implications for diabetic nephropathy.Clinical science (London, England : 1979) · 2022Article
- Regulation of NKCC2B by TNF-α in response to salt restriction.American journal of physiology. Renal physiology · 2020Article
- Pro-inflammatory Cytokines and Resistant Hypertension: Potential for Novel Treatments?Current hypertension reports · 2019Review
- Angiotensin II type 1 receptor gene polymorphism and serum angiotensin-converting enzyme level in Egyptian children with systemic lupus erythematosus.Clinical rheumatology · 2018Article
- Renal-Specific Silencing of TNF (Tumor Necrosis Factor) Unmasks Salt-Dependent Increases in Blood Pressure via an NKCC2A (NaHypertension (Dallas, Tex. : 1979) · 2018Article
- Role of renal transporters and novel regulatory interactions in the TAL that control blood pressure.Physiological genomics · 2017Review
- Effects of linagliptin on human immortalized podocytes: a cellular system to study dipeptidyl-peptidase 4 inhibition.British journal of pharmacology · 2017Article
- The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Nephrotic Syndrome-Associated Hypercholesterolemia.Circulation · 2016Article
- Histamine receptor expression in human renal tubules: a comparative pharmacological evaluation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Article
- Overactive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Tumor necrosis factor-α: regulation of renal function and blood pressure.American journal of physiology. Renal physiology · 2013Review
- Overexpression of histamine H₄ receptors in the kidney of diabetic rat.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Article
- Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHigh levels of both angiotensin (Ang) II and tumor necrosis factor (TNF)-α have been implicated in the pathogenesis of glomerular injury by affecting podocytes. The aim of this study was to investigate the Ang II-TNF-α relationship in human podocytes.
methodsImmortalized podocytes were exposed to Ang II for 6 days in the absence or presence of either losartan or PD123,319 (both at 100 nM), AT(1) and AT(2) receptor antagonists, respectively.
resultsAng II, after at least 72 h of repeated treatment, increased basal TNFA gene expression and cytokine release with a biphasic pattern and maximum response at 10 nM. Losartan dampened the effects of Ang II on TNF-α production throughout the experimental period, demonstrating an AT(1) receptor contribution. PD123,319 affected the second TNF-α production peak, showing also an AT(2) receptor contribution. Moreover, Ang II causes tumor necrosis factor receptor (TNFR) 1 and TNFR2 over-expression in a time-dependent manner. The functional interaction between Ang II and TNF-α was demonstrated when the pro-proliferative effect of Ang II was antagonized by a neutralizing TNF-α antibody.
conclusionsOur results show a functional interaction between Ang II and TNF-α and implicate this cytokine as a mediator in Ang II long-term pathoadaptive podocytes changes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.