Evidence map›Paper›PMID 22223047›Full record

ArticleTranscription

Revealing the functions of TFIIB.

Robert O J Weinzierl, Simone C Wiesler

Abstract read
In one paragraph

Article in Transcription. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Critical Involvement of TFIIB in Viral Pathogenesis.Frontiers in molecular biosciences · 2021
    Review
  3. Article
  4. High-throughput purification of affinity-tagged recombinant proteins.Journal of visualized experiments : JoVE · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Robert O J WeinzierlDepartment of Life Sciences, Imperial College London, London, UK.
Simone C Wiesler

Funding

Wellcome Trust 078043/Z/05/Z
6 · The paper itself

Abstract

The TFIIB linker domain stimulates the catalytic activity of archaeal RNAP. By characterising a range of super-stimulating mutants we identified a novel rate-limiting step in transcription initiation. Our results help to interpret structural findings and pave the way towards higher-resolution structures of the RNAP-TFIIB linker interface.

Indexed as

Protein Structure, TertiaryAmino Acid SequenceArchaeal ProteinsCrystallography, X-RayDNA-Directed RNA PolymerasesMethanococcalesModels, MolecularMutationProtein BindingSequence Homology, Amino AcidTranscription Factor TFIIBTranscription, GeneticArchaeal ProteinsDNA-Directed RNA PolymerasesTranscription Factor TFIIB

Identifiers

PMID22223047
PMCPMC3265785

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.