ArticleEnvironmental health and preventive medicine2012
Failure to detect significant association between estrogen receptor-alpha gene polymorphisms and endometriosis in Japanese women.
Article in Environmental health and preventive medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Defining the genetic profile of endometriosis.Experimental and therapeutic medicine · 2019Review
- ESR1 rs9340799 is associated with endometriosis-related infertility and in vitro fertilization failure.Disease markers · 2013Article
- Epidemiologic Factors Associated with Endometriosis in East Asia.Gynecology and minimally invasive therapyReview
- Sex hormone-related polymorphisms in endometriosis and migraine: A narrative review.Women's health (London, England)Review
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of the study was to test whether estrogen receptor 1 (ESR1) gene polymorphisms are correlated with the risk of the development of endometriosis in Japanese women, as a preliminary study.
methodsTo compare allelic frequencies and genotype distributions, a case-control study of 100 affected women and 143 women with no evidence of disease was performed using 10 microsatellite repeat markers and 66 single-nucleotide polymorphisms (SNPs) in the ESR1 gene region.
resultsAlthough our results might be insufficient to detect genetic susceptibility, owing to the small sample size and low genetic power, statistical analysis of the differences in allelic frequency between the cases and controls at each microsatellite locus demonstrated that no microsatellite locus in the ESR1 gene displayed a significant association with the disease when multiple testing was taken into account. Also, there were no statistically significant differences in the SNP allele frequencies and genotypes between the cases and controls when multiple testing was taken into account.
conclusionThe findings in our pilot study suggest that ESR1 polymorphisms do not contribute to endometriosis susceptibility.
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