ArticleCell stress & chaperones2012
Plasma Hsp72 (HSPA1A) and Hsp27 (HSPB1) expression under heat stress: influence of exercise intensity.
Article in Cell stress & chaperones, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 61 citations in OpenAlex.
- New Zealand blackcurrant extract modulates the heat shock response in men during exercise in hot ambient conditions.European journal of applied physiology · 2024Trial
- Cellular Stress Response Gene Expression During Upper and Lower Body High Intensity Exercises.PloS one · 2017Trial
- Moderate- and high-intensity exhaustive exercise in the heat induce a similar increase in monocyte Hsp72.Cell stress & chaperones · 2015Trial
- Human monocyte heat shock protein 72 responses to acute hypoxic exercise after 3 days of exercise heat acclimation.BioMed research international · 2015Trial
- Extracellular Hsp72 concentration relates to a minimum endogenous criteria during acute exercise-heat exposure.Cell stress & chaperones · 2014Trial
- Effects of heat stimulation after high-intensity interval training on serum adipokines, eHSP72, and immunoglobulins in men with obesity.Journal of exercise science and fitness · 2025Article
- Unveiling the role of exercise in modulating plasma heat shock protein 27 levels: insights for exercise immunology and cardiovascular health.Molecular and cellular biochemistry · 2025Review
- Therapeutic targets in diabetic peripheral neuropathy: heat shock proteins.Frontiers in endocrinology · 2025Review
- Carbohydrate, but not fat, oxidation is reduced during moderate-intensity exercise performed in 33 vs. 18 °C at matched heart rates.European journal of applied physiology · 2023Article
- HSP70 as a biomarker of the thin threshold between benefit and injury due to physical exercise when exposed to air pollution.Cell stress & chaperones · 2021Review
- Article
- Could Heat Therapy Be an Effective Treatment for Alzheimer's and Parkinson's Diseases? A Narrative Review.Frontiers in physiology · 2019Review
- Expression times for hsp27 and hsp70 as an indicator of thermal stress during death due to fire.International journal of legal medicine · 2017Article
- The effect of passive heating on heat shock protein 70 and interleukin-6: A possible treatment tool for metabolic diseases?Temperature (Austin, Tex.) · 2017Article
- Hsp72 and Hsp90α mRNA transcription is characterised by large, sustained changes in core temperature during heat acclimation.Cell stress & chaperones · 2016Article
- In vitro Stability of Heat Shock Protein 27 in Serum and Plasma Under Different Pre-analytical Conditions: Implications for Large-Scale Clinical Studies.Annals of laboratory medicine · 2016Article
- Hospitalized dogs recovery from naturally occurring heatstroke; does serum heat shock protein 72 can provide prognostic biomarker?Cell stress & chaperones · 2016Article
- Heat stress and dehydration in adapting for performance: Good, bad, both, or neither?Temperature (Austin, Tex.) · 2016Review
- A comparison of two commercially available ELISA methods for the quantification of human plasma heat shock protein 70 during rest and exercise stress.Cell stress & chaperones · 2015Article
- Adrenergic response to maximum exercise of trained road cyclists.Journal of human kinetics · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular heat-shock protein 72 (eHsp72) expression during exercise-heat stress is suggested to increase with the level of hyperthermia attained, independent of the rate of heat storage. This study examined the influence of exercise at various intensities to elucidate this relationship, and investigated the association between eHsp72 and eHsp27. Sixteen male subjects cycled to exhaustion at 60% and 75% of maximal oxygen uptake in hot conditions (40°C, 50% RH). Core temperature, heart rate, oxidative stress, and blood lactate and glucose levels were measured to determine the predictor variables associated with eHsp expression. At exhaustion, heart rate exceeded 96% of maximum in both conditions. Core temperature reached 39.7°C in the 60% trial (58.9 min) and 39.0°C in the 75% trial (27.2 min) (P < 0.001). The rate of rise in core temperature was 2.1°C h(-1) greater in the 75% trial than in the 60% trial (P < 0.001). A significant increase and correlation was observed between eHsp72 and eHsp27 concentrations at exhaustion (P < 0.005). eHsp72 was highly correlated with the core temperature attained (60% trial) and the rate of increase in core temperature (75% trial; P < 0.05). However, no common predictor variable was associated with the expression of both eHsps. The similarity in expression of eHsp72 and eHsp27 during moderate- and high-intensity exercise may relate to the duration (i.e., core temperature attained) and intensity (i.e., rate of increase in core temperature) of exercise. Thus, the immuno-inflammatory release of eHsp72 and eHsp27 in response to exercise in the heat may be duration and intensity dependent.
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Registered trials
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