ArticleObesity (Silver Spring, Md.)2012
Intra-abdominal adipose tissue is independently associated with sex-hormone binding globulin in premenopausal women.
Article in Obesity (Silver Spring, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Proteomic Analysis of Human Plasma during Intermittent Fasting.Journal of proteome research · 2019Trial
- Cross-sectional study of factors influencing sex hormone-binding globulin concentrations in normally cycling premenopausal women.Fertility and sterility · 2015Trial
- Trial
- Changes in uric acid metabolism and associated plasma proteomics during sex hormone therapy.Journal of clinical & translational endocrinology · 2026Article
- Sex Hormones and Cardiovascular Risk in Type 2 Diabetes: Cohort Study of the Look AHEAD Trial.Diabetes care · 2026Article
- Clinical Thresholds for Visceral Adiposity Accumulation: A Comparative Analysis in Sex-, Age-, and BMI-Matched Black and White Adults.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan.Frontiers in endocrinology · 2025Review
- Crosstalk between adipogenesis and aging: role of polyphenols in combating adipogenic-associated aging.Immunity & ageing : I & A · 2024Review
- Artificial intelligence-enhanced electrocardiography derived body mass index as a predictor of future cardiometabolic disease.NPJ digital medicine · 2024Article
- Body Composition and Its Impact on the Hormonal Disturbances in Women with Polycystic Ovary Syndrome.Nutrients · 2021Article
- Commentary: Mendelian randomization and women's health.International journal of epidemiology · 2019Article
- Association of rs6259 polymorphism with SHBG levels and Poly Cystic Ovary Syndrome in Indian population: a case control study.Molecular biology reports · 2019Article
- Ovarian volume is associated with adiposity measures and bone mineral density in postmenopausal women.Journal of musculoskeletal & neuronal interactions · 2018Article
- Visceral Adipose Tissue Accumulation and Residual Cardiovascular Risk.Current hypertension reports · 2018Review
- Proteomics reveals the effects of sustained weight loss on the human plasma proteome.Molecular systems biology · 2016Article
- The impact of supervised weight loss and intentional weight regain on sex hormone binding globulin and testosterone in premenopausal women.Systems biology in reproductive medicine · 2016Article
- Enzymatic intracrine regulation of white adipose tissue.Hormone molecular biology and clinical investigation · 2014Review
- Reduction in neural activation to high-calorie food cues in obese endometrial cancer survivors after a behavioral lifestyle intervention: a pilot study.BMC neuroscience · 2012Article
- Serum visfatin concentration and its relationship with sex hormones in obese Saudi women.International journal of health sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Lower serum concentrations of sex-hormone binding globulin (SHBG) are associated with increased risk for several obesity-related diseases in women including hormone-sensitive cancers, type 2 diabetes, metabolic syndrome, and cardiovascular disease. Previous investigations have reported that body composition, specifically central obesity, and/or higher insulin concentrations are key factors associated with lower SHBG in overweight and obese women; however, these studies were limited by their cross-sectional design. We hypothesized that intra-abdominal adipose tissue (IAAT), a fat depot linked with an abnormal metabolic profile, is inversely and independently associated with SHBG. Therefore, we determined the longitudinal associations among SHBG, insulin, and IAAT in 107 premenopausal women enrolled in a weight loss study. Overweight (BMI 27-30 kg/m(2)) women were weight reduced until BMI of ≤ 24 was achieved. Body composition and IAAT were measured at baseline and after weight loss with dual-energy X-ray absorptiometry and computed tomography, respectively. Serum concentrations of insulin and SHBG were determined. Paired t-test showed that insulin and IAAT decreased significantly and SHBG increased significantly following weight loss (P < 0.0001 for all). Simple correlations from baseline showed no association with insulin and SHBG (r = -0.142, P = 0.143) and a significant inverse association between IAAT and SHBG (r = -0.43, P < 0.0001). Repeated measures mixed-model showed that after adjusting for age and time (weight loss), IAAT was significantly inversely associated with SHBG (P = 0.0002) and there was no association with insulin and SHBG (P = 0.180). We conclude that SHBG concentrations are influenced by IAAT and not insulin in premenopausal women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.