ArticleNature protocols2012
High-throughput ballistic injection nanorheology to measure cell mechanics.
Article in Nature protocols, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Accelerated discovery of cell migration regulators using label-free deep learning-based automated tracking.Science advances · 2026Article
- Biomechanical control of vascular morphogenesis by the surrounding stiffness.Nature communications · 2025Article
- Mechanical deformation and death of circulating tumor cells in the bloodstream.Cancer metastasis reviews · 2024Review
- Fluorescence lifetime imaging microscopy of flexible and rigid dyes probes the biophysical properties of synthetic and biological membranes.Biophysical journal · 2024Article
- E-cadherin interacts with EGFR resulting in hyper-activation of ERK in multiple models of breast cancer.Oncogene · 2024Article
- Three-dimensional reconstruction of fetal rhesus macaque kidneys at single-cell resolution reveals complex inter-relation of structures.bioRxiv : the preprint server for biology · 2024Article
- Early committed polarization of intracellular tension in response to cell shape determines the osteogenic differentiation of mesenchymal stromal cells.Acta biomaterialia · 2023Article
- Single probes and resonant four-wave-mixing enabling novel correlative light electron microscopy workflow.Light, science & applications · 2023Article
- Correlative light-electron microscopy using small gold nanoparticles as single probes.Light, science & applications · 2023Article
- Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tension.PNAS nexus · 2023Article
- CODA: quantitative 3D reconstruction of large tissues at cellular resolution.Nature methods · 2022Article
- The microRNA-210-Stathmin1 Axis Decreases Cell Stiffness to Facilitate the Invasiveness of Colorectal Cancer Stem Cells.Cancers · 2021Article
- Particle tracking microrheology of cancer cells in living subjects.Materials today (Kidlington, England) · 2020Article
- Article
- Towards the directed evolution of protein materials.MRS communications · 2019Article
- Review
- Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts.Chemical reviews · 2018Review
- Epithelial-mesenchymal transition softens head and neck cancer cells to facilitate migration in 3D environments.Journal of cellular and molecular medicine · 2018Article
- A comparison of methods to assess cell mechanical properties.Nature methods · 2018Article
- Force Spectrum Microscopy Using Mitochondrial Fluctuations of Control and ATP-Depleted Cells.Biophysical journal · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
High-throughput ballistic injection nanorheology is a method for the quantitative study of cell mechanics. Cell mechanics are measured by ballistic injection of submicron particles into the cytoplasm of living cells and tracking the spontaneous displacement of the particles at high spatial resolution. The trajectories of the cytoplasm-embedded particles are transformed into mean-squared displacements, which are subsequently transformed into frequency-dependent viscoelastic moduli and time-dependent creep compliance of the cytoplasm. This method allows for the study of a wide range of cellular conditions, including cells inside a 3D matrix, cell subjected to shear flows and biochemical stimuli, and cells in a live animal. Ballistic injection lasts <1 min and is followed by overnight incubation. Multiple particle tracking for one cell lasts <1 min. Forty cells can be examined in <1 h.
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