ArticleThe American journal of the medical sciences2012
Premature atherosclerosis is associated with hypovitaminosis D and angiotensin-converting enzyme inhibitor non-use in lupus patients.
Article in The American journal of the medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- The clinical significance of vitamin D in systemic lupus erythematosus: a systematic review.PloS one · 2013Pooled it
- A Pilot Study to Determine if Vitamin D Repletion Improves Endothelial Function in Lupus Patients.The American journal of the medical sciences · 2015Trial
- Systemic lupus in the era of machine learning medicine.Lupus science & medicine · 2024Review
- Extent of vascular plaque predicts future cardiovascular events in patients with systemic lupus erythematosus.Rheumatology (Oxford, England) · 2022Article
- Exploration of ACE-Inhibiting Peptides Encrypted inBioMed research international · 2022Article
- Hydroxychloroquine Alleviates EAU by Inhibiting Uveitogenic T Cells and Ameliorating Retinal Vascular Endothelial Cells Dysfunction.Frontiers in immunology · 2022Article
- An introduction to machine learning and analysis of its use in rheumatic diseases.Nature reviews. Rheumatology · 2021Review
- Cutaneous lupus erythematosus and cardiovascular disease: current knowledge and insights into pathogenesis.Clinical rheumatology · 2021Review
- Plasma Sphingolipid Profile Associated With Subclinical Atherosclerosis and Clinical Disease Markers of Systemic Lupus Erythematosus: Potential Predictive Value.Frontiers in immunology · 2021Article
- Atherosclerosis in SLE: a potential role for serum parathormone levels.Lupus science & medicine · 2020Article
- ASSOCIATIONS BETWEEN ACCELERATED ATHEROSCLEROSIS, OXIDIZED LDL IMMUNE COMPLEXES, AND IN VITRO ENDOTHELIAL DYSFUNCTION IN SYSTEMIC LUPUS ERYTHEMATOSUS.Transactions of the American Clinical and Climatological Association · 2020Article
- Calcium and vitamin D supplement intake may increase arterial stiffness in systemic lupus erythematosus patients.Clinical rheumatology · 2019Article
- Autoimmune Disease-Associated Hypertension.Current hypertension reports · 2019Review
- The Impact of Vitamin D on the Immunopathophysiology, Disease Activity, and Extra-Musculoskeletal Manifestations of Systemic Lupus Erythematosus.International journal of molecular sciences · 2018Review
- Angiotensin-Converting Enzyme Gene I/D Polymorphism Is Associated With Systemic Lupus Erythematosus Susceptibility: An Updated Meta-Analysis and Trial Sequential Analysis.Frontiers in physiology · 2018Article
- The effect of vitamin D on disease activity, fatigue and interferon signature gene expression in systemic lupus erythematosus.Mediterranean journal of rheumatology · 2017Review
- Vitamin D treatment for connective tissue diseases: hope beyond the hype?Rheumatology (Oxford, England) · 2017Review
- Novel Insights in Systemic Lupus Erythematosus and Atherosclerosis.Frontiers in medicine · 2017Review
- Autoimmune therapeutic chloroquine lowers blood pressure and improves endothelial function in spontaneously hypertensive rats.Pharmacological research · 2016Article
- Immunomodulators in SLE: Clinical evidence and immunologic actions.Journal of autoimmunity · 2016Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The ultimate goal is to identify and target modifiable risk factors that will reduce major cardiovascular events in African American lupus patients. As a first step toward achieving this goal, this study was designed to explore risk factor models of preclinical atherosclerosis in a predominantly African American group of patients with systemic lupus erythematosus (SLE) using variables historically associated with endothelial function in nonlupus populations. Fifty-one subjects with SLE but without a history of clinical cardiovascular events were enrolled. At entry, a Framingham risk factor history and medication list were recorded. Sera and plasma samples were analyzed for lipids, lupus activity markers and total 25-hydroxyvitamin D (25 OH)D) levels. Carotid ultrasound measurements were performed to determine total plaque area (TPA) in both carotids. Cases had TPA values above age-matched controls from a vascular prevention clinic population. Logistic regression and machine learning analyses were performed to create predictive models. 25(OH)D levels were significantly lower, and SLE disease duration was significantly higher in cases. 25(OH)D levels inversely correlated with age-adjusted TPA. Angiotensin-converting enzyme (ACE) inhibitor nonuse associated with case status. Logistic regression models containing ACE inhibitor use, 25(OH)D levels and low-density lipoprotein levels had a diagnostic accuracy of 84% for predicting accelerated atherosclerosis. Similar results were obtained with machine learning models, but hydroxychlo-roquine use associated with controls in these models. This is the first study to demonstrate an association between atherosclerotic burden and 25(OH)D insufficiency or ACE inhibitor nonuse in lupus patients. These findings provide strong rationale for the study of ACE inhibitors and vitamin D replenishment as preventive therapies in this high-risk population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.