ArticleDiseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
Squamous cell carcinoma in Barrett's esophagus: field effect versus metastasis.
Article in Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Two Cancers in One Barrett's Segment: First Report of Concurrent Squamous Cell Carcinoma and Adenocarcinoma.GE Portuguese journal of gastroenterology · 2023Article
- The decisive role of molecular pathology in presumed somatic metastases of type II testicular germ cell tumors: report of 2 cases.Diagnostic pathology · 2020Article
- A Primary Barrett's Adenocarcinoma with a Squamous Cell Carcinoma Component.Internal medicine (Tokyo, Japan) · 2019Article
- Adenosquamous Carcinoma of the Esophagus: A Literature Review.Journal of translational internal medicine · 2018Article
- Squamous cell carcinoma after radiofrequency ablation for Barrett's dysplasia.World journal of gastroenterology · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Barrett's esophagus (BE) is a premalignant condition with an increased risk of developing esophageal adenocarcinoma (EAC). Risk factors for EAC overlap with those for esophageal squamous cell carcinoma (ESCC), but ESCC is surprisingly rare in BE. We report two cases of ESCC directly surrounded by BE. Both patients had a previous medical history of cancers, i.e., head and neck squamous cell carcinomas, and were using alcohol and smoking tobacco. Using immunohistochemistry for p63, CK5, CK7, and CDX2, it was confirmed that these carcinomas were pure squamous cell carcinomas, and not EACs or esophageal adenosquamous carcinomas arising from BE. Using TP53 mutation and loss of heterozygosity analysis, we established that the ESCCs in BE were not metastases of the previously diagnosed head and neck squamous cell carcinomas but de novo primary ESCCs. This study shows the strength of molecular analysis as an adjunct to the histopathologic diagnosis for distinguishing between metastases of prior cancers and primary cancers. Furthermore, these cases imply that presence of BE is not protective with regards to developing ESCC in the lower one third of the esophagus. We suggest that their ESCCs arose from islets of squamous epithelium in BE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.