ArticleBMC research notes2012
Adherence to isoniazid preventive therapy in Indonesian children: A quantitative and qualitative investigation.
Article in BMC research notes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Strategies to detect and manage latent tuberculosis infection among household contacts of pulmonary TB patients in high TB burden countries - a systematic review and meta-analysis.Tropical medicine & international health : TM & IH · 2022Pooled it
- Child contact management in high tuberculosis burden countries: A mixed-methods systematic review.PloS one · 2017Pooled it
- Adherence to isoniazid preventive therapy among child contacts in Rwanda: A mixed-methods study.PloS one · 2019Trial
- The effectiveness of preventive tuberculosis treatment in children.BMC infectious diseases · 2026Article
- Factors Associated with Parental Involvement in Efforts to Prevent Drug-Resistant Tuberculosis in Children: A Scoping Review.Infection and drug resistance · 2026Review
- A study protocol on assessing the acceptance and effectiveness of a digital adherence technology for TB preventive treatment in Bangladesh.BMC public health · 2025Observational
- Knowledge, enablers, and barriers to TB preventive treatment among health care workers.Public health action · 2025Article
- Evaluating community knowledge of tuberculosis preventive therapy in rural South Africa.BMC public health · 2025Article
- Article
- Children and providers' perspectives on once-weekly rifapentine and isoniazid TB preventive therapy.IJTLD open · 2025Article
- High Tuberculosis Preventive Treatment Uptake and Completion Rates Using a Person-Centered Approach among Tuberculosis Household Contact in Yogyakarta.Tropical medicine and infectious disease · 2023Article
- TB preventive therapy preferences among children and adolescents.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2023Article
- They do not have symptoms - why do they need to take medicines? Challenges in tuberculosis preventive treatment among children in Cambodia: a qualitative study.BMC pulmonary medicine · 2023Article
- Implementation of an integrated care strategy for child contacts of tuberculosis patients: a quasi-experimental study protocol.BMC pediatrics · 2023Article
- Article
- Social Determinants of Adherence to Treatment for Tuberculosis Infection and Disease Among Children, Adolescents, and Young Adults: A Narrative Review.Journal of the Pediatric Infectious Diseases Society · 2022Review
- Barriers and facilitators for isoniazid preventive therapy (IPT) administration in children under 5 years of age in the Dominican Republic.BMC infectious diseases · 2022Article
- Article
- Barriers and strategies to successful tuberculosis treatment in a high-burden tuberculosis setting: a qualitative study from the patient's perspective.BMC public health · 2021Article
- Caregivers' knowledge and perceptions are associated with children's TB preventive treatment completion.Public health action · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is recommended that young child contacts of sputum smear positive tuberculosis cases receive isoniazid preventive therapy (IPT) but reported adherence is low and risk factors for poor adherence in children are largely unknown.
methodsWe prospectively determined rates of IPT adherence in children < 5 yrs in an Indonesian lung clinic. Possible risk factors for poor adherence, defined as ≤3 months prescription collection, were calculated using logistic regression. To further investigate adherence barriers in-depth interviews were conducted with caregivers of children with good and poor adherence.
resultsEighty-two children eligible for IPT were included, 61 (74.4%) of which had poor adherence. High transport costs (OR 3.3, 95% CI 1.1-10.2) and medication costs (OR 20.0, 95% CI 2.7-414.5) were significantly associated with poor adherence in univariate analysis. Access, medication barriers, disease and health service experience and caregiver TB and IPT knowledge and beliefs were found to be important determinants of adherence in qualitative analysis.
conclusionAdherence to IPT in this setting in Indonesia is extremely low and may result from a combination of financial, knowledge, health service and medication related barriers. Successful reduction of childhood TB urgently requires evidence-based interventions that address poor adherence to IPT.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.