ArticleAging cell2012
Mapping of quantitative trait loci controlling lifespan in the short-lived fish Nothobranchius furzeri--a new vertebrate model for age research.
Article in Aging cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 81 citations in OpenAlex.
- Resolving repetitive and telomeric regions through a high-contiguity genome assembly of the African Turquoise killifish.Genes & genomics · 2026Article
- Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish.Nature aging · 2026Article
- The genome of the MZM-0403 strain of the African turquoise killifish, Nothobranchius furzeri.G3 (Bethesda, Md.) · 2025Article
- Analysis of microRNA expression reveals convergent evolution of the molecular control of diapause in annual killifishes.Frontiers in genetics · 2025Article
- Dynamics of Wnt/β-catenin reporter activity throughout whole life in a naturally short-lived vertebrate.npj aging · 2024Article
- The African Turquoise Killifish: A Scalable Vertebrate Model for Aging and Other Complex Phenotypes.Cold Spring Harbor protocols · 2024Article
- The Utility of Small Fishes for the Genetic Study of Human Age-Related Disorders.Frontiers in genetics · 2022Article
- Genetic Dissection of a Precocious Phenotype in Male Tiger Pufferfish (Takifugu rubripes) using Genotyping by Random Amplicon Sequencing, Direct (GRAS-Di).Marine biotechnology (New York, N.Y.) · 2021Article
- Nothobranchius annual killifishes.EvoDevo · 2020Review
- Article
- celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish.eLife · 2020Article
- Review
- Review
- The African turquoise killifish: A research organism to study vertebrate aging and diapause.Aging cell · 2018Review
- A Protocol for Laboratory Housing of Turquoise Killifish (Nothobranchius furzeri).Journal of visualized experiments : JoVE · 2018Article
- Translocator protein (18 kDa): an update on its function in steroidogenesis.Journal of neuroendocrinology · 2018Review
- Experimental Models for Aging and their Potential for Novel Drug Discovery.Current neuropharmacology · 2018Review
- Non-model model organisms.BMC biology · 2017Article
- Efficient genome engineering approaches for the short-lived African turquoise killifish.Nature protocols · 2016Article
- Laboratory breeding of the short-lived annual killifish Nothobranchius furzeri.Nature protocols · 2016Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The African annual fish Nothobranchius furzeri emerged as a new model for age research over recent years. Nothobranchius furzeri show an exceptionally short lifespan, age-dependent cognitive/behavioral decline, expression of age-related biomarkers, and susceptibility to lifespan manipulation. In addition, laboratory strains differ largely in lifespan. Here, we set out to study the genetics of lifespan determination. We crossed a short- to a long-lived strain, recorded lifespan, and established polymorphic markers. On the basis of genotypes of 411 marker loci in 404 F(2) progeny, we built a genetic map comprising 355 markers at an average spacing of 5.5 cM, 22 linkage groups (LGs) and 1965 cM. By combining marker data with lifespan values, we identified one genome-wide highly significant quantitative trait locus (QTL) on LG 9 (P < 0.01), which explained 11.3% of the F(2) lifespan variance, and three suggestive QTLs on LG 11, 14, and 17. We characterized the highly significant QTL by synteny analysis, because a genome sequence of N. furzeri was not available. We located the syntenic region on medaka chromosome 5, identified candidate genes, and performed fine mapping, resulting in a c. 40% reduction of the initial 95% confidence interval. We show both that lifespan determination in N. furzeri is polygenic, and that candidate gene detection is easily feasible by cross-species analysis. Our work provides first results on the way to identify loci controlling lifespan in N. furzeri and illustrates the potential of this vertebrate species as a genetic model for age research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.