ArticleAstrobiology2012
Spaceflight transcriptomes: unique responses to a novel environment.
Article in Astrobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 139 citations in OpenAlex.
- Functional Meta-Analysis of the Proteomic Responses of Arabidopsis Seedlings to the Spaceflight Environment Reveals Multi-Dimensional Sources of Variability across Spaceflight Experiments.International journal of molecular sciences · 2023Pooled it
- Suborbital spaceflight reveals rapid changes in gene expression accompanying the transition to and from space.NPJ microgravity · 2026Article
- Gravity as a Boundary Condition for the Evolution of Three-Dimensional Multicellularity.Life (Basel, Switzerland) · 2026Article
- Potential regulatory modules to integrate microgravity signals into flowering pathways in Arabidopsis thaliana grown in space.NPJ microgravity · 2025Article
- Light has a principal role in the Arabidopsis transcriptomic response to the spaceflight environment.NPJ microgravity · 2024Article
- Transcriptional response of Arabidopsis thaliana's root-tip to spaceflight.Plant molecular biology · 2024Article
- Conserved mechanisms of self-renewal and pluripotency in mouse and human ESCs regulated by simulated microgravity using a 3D clinostat.Cell death discovery · 2024Article
- Impact of modeled microgravity stress on innate immunity in a beneficial animal-microbe symbiosis.Scientific reports · 2024Article
- Transcriptomic dynamics in the transition from ground to space are revealed by Virgin Galactic human-tended suborbital spaceflight.NPJ microgravity · 2023Article
- Microgravity and evasion of plant innate immunity by human bacterial pathogens.NPJ microgravity · 2023Review
- Meta-analysis of the space flight and microgravity response of the Arabidopsis plant transcriptome.NPJ microgravity · 2023Article
- Article
- Transcriptome profiles of rice roots under simulated microgravity conditions and following gravistimulation.Frontiers in plant science · 2023Article
- Integrative transcriptomics and proteomics profiling ofFrontiers in plant science · 2023Article
- Challenges and considerations for single-cell and spatially resolved transcriptomics sample collection during spaceflight.Cell reports methods · 2022Review
- Red Light Enhances Plant Adaptation to Spaceflight and MarsLife (Basel, Switzerland) · 2022Review
- Plants in Microgravity: Molecular and Technological Perspectives.International journal of molecular sciences · 2022Review
- Microgravity enhances the phenotype of Arabidopsis zigzag-1 and reduces the Wortmannin-induced vacuole fusion in root cells.NPJ microgravity · 2022Article
- Recent transcriptomic studies to elucidate the plant adaptive response to spaceflight and to simulated space environments.iScience · 2022Review
- Conducting Plant Experiments in Space and on the Moon.Methods in molecular biology (Clifton, N.J.) · 2022Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spaceflight environment presents unique challenges to terrestrial biology, including but not limited to the direct effects of gravity. As we near the end of the Space Shuttle era, there remain fundamental questions about the response and adaptation of plants to orbital spaceflight conditions. We address a key baseline question of whether gene expression changes are induced by the orbital environment, and then we ask whether undifferentiated cells, cells presumably lacking the typical gravity response mechanisms, perceive spaceflight. Arabidopsis seedlings and undifferentiated cultured Arabidopsis cells were launched in April, 2010, as part of the BRIC-16 flight experiment on STS-131. Biologically replicated DNA microarray and averaged RNA digital transcript profiling revealed several hundred genes in seedlings and cell cultures that were significantly affected by launch and spaceflight. The response was moderate in seedlings; only a few genes were induced by more than 7-fold, and the overall intrinsic expression level for most differentially expressed genes was low. In contrast, cell cultures displayed a more dramatic response, with dozens of genes showing this level of differential expression, a list comprised primarily of heat shock-related and stress-related genes. This baseline transcriptome profiling of seedlings and cultured cells confirms the fundamental hypothesis that survival of the spaceflight environment requires adaptive changes that are both governed and displayed by alterations in gene expression. The comparison of intact plants with cultures of undifferentiated cells confirms a second hypothesis: undifferentiated cells can detect spaceflight in the absence of specialized tissue or organized developmental structures known to detect gravity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.