ArticlePhotochemistry and photobiology
Lysosomal signaling enhances mitochondria-mediated photodynamic therapy in A431 cancer cells: role of iron.
Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Novel Pyrroloquinoline Quinone-Modified Cerium Oxide Nanoparticles and Their Selective Cytotoxicity Under X-Ray Irradiation.Antioxidants (Basel, Switzerland) · 2024Article
- The mitochondrial calcium uniporter mediates mitochondrial FeToxicology and applied pharmacology · 2023Article
- Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy.Medicines (Basel, Switzerland) · 2021Review
- Ammonium Ferric Citrate induced Ferroptosis in Non-Small-Cell Lung Carcinoma through the inhibition of GPX4-GSS/GSR-GGT axis activity.International journal of medical sciences · 2021Article
- Article
- Rare-Earth-Doped Calcium Carbonate Exposed to X-ray Irradiation to Induce Reactive Oxygen Species for Tumor Treatment.International journal of molecular sciences · 2019Article
- Photodynamic Efficiency: From Molecular Photochemistry to Cell Death.International journal of molecular sciences · 2015Review
- Apoptosis and associated phenomena as a determinants of the efficacy of photodynamic therapy.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2015Review
- Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin.The Journal of biological chemistry · 2014Article
- Mitoferrin-2-dependent mitochondrial iron uptake sensitizes human head and neck squamous carcinoma cells to photodynamic therapy.The Journal of biological chemistry · 2013Article
- Photosensitizer adhered to cell culture microplates induces phototoxicity in carcinoma cells.BioMed research international · 2013Article
- Improving the endosomal escape of cell-penetrating peptides and their cargos: strategies and challenges.Pharmaceuticals (Basel, Switzerland) · 2012Review
- Promotion of Proapoptotic Signals by Lysosomal Photodamage.Photochemistry and photobiologyArticle
- Enhanced efficacy of photodynamic therapy via a sequential targeting protocol.Photochemistry and photobiologyArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In photodynamic therapy (PDT), light activates a photosensitizer added to a tissue, resulting in singlet oxygen formation and cell death. The photosensitizer phthalocyanine 4 (Pc 4) localizes primarily to mitochondrial membranes in cancer cells, resulting in mitochondria-mediated cell death. The aim of this study was to determine how lysosomes contribute to PDT-induced cell killing by mitochondria-targeted photosensitizers such as Pc 4. We monitored cell killing of A431 cells after Pc 4-PDT in the presence and absence of bafilomycin, an inhibitor of the vacuolar proton pump of lysosomes and endosomes. Bafilomycin was not toxic by itself, but greatly enhanced Pc 4-PDT-induced cell killing. To investigate whether iron loading of lysosomes affects bafilomycin-induced killing, cells were incubated with ammonium ferric citrate (30 μM) for 30 h prior to PDT. Ammonium ferric citrate enhanced Pc 4 plus bafilomycin-induced cell killing without having toxicity by itself. Iron chelators (desferrioxamine and starch-desferrioxamine) and the inhibitor of the mitochondrial calcium (and ferrous iron) uniporter, Ru360, protected against Pc 4 plus bafilomycin toxicity. These results support the conclusion that chelatable iron stored in the lysosomes enhances the efficacy of bafilomycin-mediated PDT and that lysosomal disruption augments PDT with Pc 4.
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