ArticlePloS one2011
Mitotic spindle orients perpendicular to the forces imposed by dynamic shear.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Mechanical stretching determines the orientation of osteoblast migration and cell division.Anatomical science international · 2023Article
- Isotropic myosin-generated tissue tension is required for the dynamic orientation of the mitotic spindle.Molecular biology of the cell · 2020Article
- A Biophysical Model for Curvature-Guided Cell Migration.Biophysical journal · 2019Article
- Review
- Adaptive responses of murine osteoblasts subjected to coupled mechanical stimuli.Journal of the mechanical behavior of biomedical materials · 2018Article
- Colloquium: Mechanical formalisms for tissue dynamics.The European physical journal. E, Soft matter · 2015Article
- Force and the spindle: mechanical cues in mitotic spindle orientation.Seminars in cell & developmental biology · 2014Review
- Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenance.Cell cycle (Georgetown, Tex.) · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
Orientation of the division axis can determine cell fate in the presence of morphogenetic gradients. Understanding how mitotic cells integrate directional cues is therefore an important question in embryogenesis. Here, we investigate the effect of dynamic shear forces on confined mitotic cells. We found that human epithelial cells (hTERT-RPE1) as well as MC3T3 osteoblasts align their mitotic spindle perpendicular to the external force. Spindle orientation appears to be a consequence of cell elongation along the zero-force direction in response to the dynamic shear. This process is a nonlinear response to the strain amplitude, requires actomyosin activity and correlates with redistribution of myosin II. Mechanosteered cells divide normally, suggesting that this mechanism is compatible with biological functions.
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Registered trials
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