ArticlePLoS computational biology2011
Radial and spiral stream formation in Proteus mirabilis colonies.
Article in PLoS computational biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 1 citations in OpenAlex.
- An agent-based model of Trypanosoma brucei social motility to explore determinants of colony pattern formation.PLoS computational biology · 2026Article
- Multiscale phenomena and patterns in biological systems: special issue in honour of Hans Othmer.Journal of mathematical biology · 2020Article
- Spatial pattern formation in reaction-diffusion models: a computational approach.Journal of mathematical biology · 2020Article
- Chirality in microbial biofilms is mediated by close interactions between the cell surface and the substratum.The ISME journal · 2017Article
- Switches induced by quorum sensing in a model of enzyme-loaded microparticles.Journal of the Royal Society, Interface · 2017Article
- Symmetry and reduction in collectives: low-dimensional cyclic pursuit.Proceedings. Mathematical, physical, and engineering sciences · 2016Article
- Moment-flux models for bacterial chemotaxis in large signal gradients.Journal of mathematical biology · 2016Article
- Proteus mirabilis and Urinary Tract Infections.Microbiology spectrum · 2015Review
- Macroscopic equations for bacterial chemotaxis: integration of detailed biochemistry of cell signaling.Journal of mathematical biology · 2015Article
- Stochastic analysis of reaction-diffusion processes.Bulletin of mathematical biology · 2014Article
- Excitation and adaptation in bacteria-a model signal transduction system that controls taxis and spatial pattern formation.International journal of molecular sciences · 2013Article
- Noise Induced Pattern Switching in Randomly Distributed Delayed Swarms.Proceedings of the ... American Control Conference. American Control Conference · 2013Article
- Statistical multimoment bifurcations in random-delay coupled swarms.Physical review. E, Statistical, nonlinear, and soft matter physics · 2012Article
- The Intersection of Theory and Application in Elucidating Pattern Formation in Developmental Biology.Mathematical modelling of natural phenomena · 2009Article
- MULTISCALE MODELS OF TAXIS-DRIVEN PATTERNING IN BACTERIAL POPULATIONS.SIAM journal on applied mathematics · 2009Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The enteric bacterium Proteus mirabilis, which is a pathogen that forms biofilms in vivo, can swarm over hard surfaces and form a variety of spatial patterns in colonies. Colony formation involves two distinct cell types: swarmer cells that dominate near the surface and the leading edge, and swimmer cells that prefer a less viscous medium, but the mechanisms underlying pattern formation are not understood. New experimental investigations reported here show that swimmer cells in the center of the colony stream inward toward the inoculation site and in the process form many complex patterns, including radial and spiral streams, in addition to previously-reported concentric rings. These new observations suggest that swimmers are motile and that indirect interactions between them are essential in the pattern formation. To explain these observations we develop a hybrid model comprising cell-based and continuum components that incorporates a chemotactic response of swimmers to a chemical they produce. The model predicts that formation of radial streams can be explained as the modulation of the local attractant concentration by the cells, and that the chirality of the spiral streams results from a swimming bias of the cells near the surface of the substrate. The spatial patterns generated from the model are in qualitative agreement with the experimental observations.
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