ArticleMolecular vision2011
Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction, by activating BK channels.
Article in Molecular vision, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Effect of topical isopropyl unoprostone on macular atrophy progression in eyes with exudative age-related macular degeneration.Medicine · 2017Trial
- Effect of aortic smooth muscle BK channels on mediating chronic intermittent hypoxia-induced vascular dysfunction.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2024Article
- Implantable sustained-release drug delivery systems: a revolution for ocular therapeutics.International ophthalmology · 2023Review
- PKM2 Is a Potential Diagnostic and Therapeutic Target for Retinitis Pigmentosa.Disease markers · 2021Article
- Oxidative stress, autophagy and airway ion transport.American journal of physiology. Cell physiology · 2019Review
- Oxidative Stress-Related Molecular Biomarker Candidates for Glaucoma.Investigative ophthalmology & visual science · 2017Article
- Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone).Oxidative medicine and cellular longevity · 2017Review
- A role of Heat Shock Protein 70 in Photoreceptor Cell Death: Potential as a Novel Therapeutic Target in Retinal Degeneration.CNS neuroscience & therapeutics · 2016Review
- Integrated Approaches to Drug Discovery for Oxidative Stress-Related Retinal Diseases.Oxidative medicine and cellular longevity · 2016Review
- Unoprostone activation of BK (KCa1.1) channel splice variants.Biochimica et biophysica acta · 2015Article
- The effect of triamcinolone acetonide on laser-induced choroidal neovascularization in mice using a hypoxia visualization bio-imaging probe.Scientific reports · 2015Article
- Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light.Scientific reports · 2014Article
- Regeneration of optic nerve fibers with unoprostone, a prostaglandin-related antiglaucoma drug, in adult cats.Japanese journal of ophthalmology · 2014Article
- An evidence-based review of unoprostone isopropyl ophthalmic solution 0.15% for glaucoma: place in therapy.Clinical ophthalmology (Auckland, N.Z.) · 2014Review
- Topical isopropyl unoprostone for retinitis pigmentosa: microperimetric results of the phase 2 clinical study.Ophthalmology and therapy · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeUnoprostone isopropyl (unoprostone) is a docosanoid currently used as an antiglaucoma agent. Unoprostone is known to have neuroprotective effects and to activate large conductance Ca²⁺-activated K⁺ (BK) channels. Recently, unoprostone has been tested in clinical studies as a therapeutic agent for retinitis pigmentosa (RP) and studies have demonstrated an improvement in retinal sensitivity and in the protection of central retinal sensitivity with its use. However, the mechanism of action underlying unoprostone's protective effect in RP is not fully known. It is well known that the pathogenesis of RP can be accelerated by oxidative stress or light irradiation. Therefore, the current study investigated the effects and the underlying mechanism of action of unoprostone on oxidative stress- and light irradiation-induced damage in photoreceptor and retinal pigment epithelial cultures.
methodsThe study used the mouse retinal cone-cell line 661W to investigate the effects of unoprostone and its major metabolite, unoprostone-free acid (M1), on oxidative stress- or light irradiation-induced cell death, and a human retinal pigment epithelial cell line (ARPE-19), was used to investigate the effects on light-induced disruption of phagocytotic function in a latex bead assay. Additionally, we examined whether the effects of unoprostone and M1 were mediated by BK channels using iberiotoxin, a selective inhibitor of BK channels.
resultsUnoprostone and M1 protected against light- or H₂O₂-induced cell death in 661W cells, and against light-induced phagocytotic dysfunction in ARPE-19 cells. Additionally, iberiotoxin inhibited the protective effects of unoprostone and M1.
conclusionsThese findings indicate that unoprostone has protective effects on oxidative stress- and light irradiation-induced damage in vitro and that these effects are mediated by activation of BK channels. This confirms that unoprostone represents a promising therapeutic agent for the treatment of RP and other retinal diseases.
Indexed as
Identifiers
22219651PMC3250378W2103717111What OpenQuestion holds
Registered trials
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